Nikolaos G. Sgourakis

Children's Hospital of Philadelphia — United States

Immunology and Microbiology · Life Sciences

33h-index4.8kcitations150works3.02yr avg
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Research Topics

Immunotherapy and Immune Responses(44), T-cell and B-cell Immunology(35), vaccines and immunoinformatics approaches(28), Immune Cell Function and Interaction(27), Protein Structure and Dynamics(25)

Publications149 total

Design of solubly expressed miniaturized SMART MHCs
Proceedings of the National Academy of Sciences·2026Open Access
High-Throughput Production of Class I MHC Tetramers for Immunological Studies Using Chaperone-Mediated Peptide Exchange
Methods in molecular biology·2026
HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors
Science Advances·2026Open Access
Atomically accurate de novo design of antibodies with RFdiffusion
Nature·2025· 24 citedOpen Access
Structural mechanism of anti-MHC-I antibody blocking of inhibitory NK cell receptors in tumor immunity
2025Open Access
Optimizing the donor matching process in solid organ transplantation
Human Immunology·2025
A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens
Structure·2025· 2 citedOpen Access
Solution mapping of MHC-I:TCR interactions using a minimalistic protein system
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
Design of solubly expressed miniaturized SMART MHCs
2025· 1 citedOpen Access
CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading
Proceedings of the National Academy of Sciences·2025· 7 citedOpen Access
Ready-to-load MHC-I Nanoparticles for High-throughput T cell Screening Studies
2024· 1 citedOpen Access
Targeting peptide antigens using a multiallelic MHC I-binding system
Nature Biotechnology·2024· 20 citedOpen Access
Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network
Journal of Molecular Biology·2024Open Access
Dynamic sampling of a surveillance state enables DNA proofreading by Cas9
Cell chemical biology·2024· 7 citedOpen Access
Regulating IL-2 immune signaling function via a core allosteric structural network
2024Open Access
CryoEM structure of an MHC-I/TAPBPR peptide bound intermediate reveals the mechanism of antigen proofreading
2024Open Access
A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens
2024· 2 citedOpen Access
Exploring engineered HLA-I chaperones for enhancing the immunogenicity of cold tumors.
The Journal of Immunology·2024
The Virtual Child
Cancer Discovery·2024· 5 citedOpen Access
Abstract 2443 Expanding the applications of open MHC-I molecules for enhanced thermostability and peptide loading to HLA-A*11:01 and HLA-C*07:02 allotypes
Journal of Biological Chemistry·2024Open Access
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Frequent Co-authors

David Baker(16), Andrew C. McShan(13), Santrupti Nerli(12), Jugmohit Toor(6), Angel E. Garcı́a(5), Hau V. Truong(5), John M. Maris(5), Kannan Natarajan(5), David H. Margulies(5), Yi Sun(5), Scott E. Boyken(4), Frank DiMaio(4), P. Rossi(4), G.T. Montelione(4), Mark Yarmarkovich(4), Sarvind Tripathi(4), Son Nguyen(4), Jiansheng Jiang(4), Lisa F. Boyd(4), Ad Bax(4)