Francesca Margara

University of Oxford — United Kingdom

Medicine · Health Sciences

9h-index1.1kcitations26works0.32yr avg
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Research Topics

Cardiomyopathy and Myosin Studies(15), Cardiac electrophysiology and arrhythmias(13), Cardiovascular Function and Risk Factors(10), Neuroscience and Neural Engineering(7), Congenital heart defects research(5)

Publications26 total

Calibration and validation strategy for electromechanical cardiac digital twins
2025· 1 citedOpen Access
Calibration and validation strategy for electromechanical cardiac digital twins
2025Open Access
Calibration and validation strategy for electromechanical cardiac digital twins
2025Open Access
Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human <i>MYBPC3</i> HCM
Circulation Research·2023· 31 citedOpen Access
A Human-Based Computational Investigation Into Sarcomeric and Ionic Remodelling in Hypertrophic Cardiomyopathy
Computing in cardiology·2022Open Access
Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy
Scientific Reports·2022· 38 citedOpen Access
Human iPSC-CMs and in-silico technologies define mechanisms and accelerate targeted pharmacogenetics in hypertrophic cardiomyopathy
2022· 2 citedOpen Access
Modelling and in silico simulation of human induced pluripotent stem cell derived cardiomyocyte electro-mechanical properties
Cardiovascular Research·2022
Pharmacological Management of Hypertrophic Cardiomyopathy: From Bench to Bedside
Drugs·2022· 54 citedOpen Access
Contraction and electrophysiological abnormalities in myofilament mutation-positive and mutation-negative human HCM myocardium
Biophysical Journal·2022Open Access
In Silico Identification of the Key Ionic Currents Modulating Human Pluripotent Stem Cell-Derived Cardiomyocytes Towards an Adult Phenotype
2021 Computing in Cardiology (CinC)·2021· 4 cited
Mavacamten Efficacy in Mutation-specific Hypertrophic Cardiomyopathy: an In Silico Approach to Inform Precision Medicine
2021 Computing in Cardiology (CinC)·2021· 9 cited
In Silico Human Induced Pluripotent Stem Cell Derived Cardiomyocyte Electro-Mechanical Modelling and Simulation
2021 Computing in Cardiology (CinC)·2021
Abstract 402: Defining Diverse Disease Pathomechanisms Across Thick And Thin Filament Hypertrophic Cardiomyopathy Variants.
Circulation Research·2021· 3 cited
Combining human-based in silico and in vitro models of inherited cardiac diseases for drug safety and efficacy evaluation
Journal of Pharmacological and Toxicological Methods·2021
CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes
Circulation Research·2021· 56 citedOpen Access
Computational investigation of drug-induced effects on human cardiac electro-mechanics
EP Europace·2021· 3 citedOpen Access
Human-based computational and experimental investigation of disease mechanisms in mutation-specific hypertrophic cardiomyopathy
EP Europace·2021Open Access
Human-based computational investigations into cardiac electromechanical alterations caused by drugs and hypertrophic cardiomyopathy
Oxford University Research Archive (ORA) (University of Oxford)·2021Open Access
Human Ventricular Modelling and Simulation of Drug Action on Electrophysiology and Contraction
Computing in cardiology·2020· 1 citedOpen Access
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Frequent Co-authors

Alfonso Bueno‐Orovio(14), Blanca Rodríguez(13), Zhinuo Jenny Wang(9), Blanca Rodríguez(9), Mariano Vázquez(6), Yiangos Psaras(6), Christopher N. Toepfer(6), Rubén Doste(6), Francesc Levrero-Florencio(4), Giuliana G. Repetti(4), Manuel Schmid(4), Jonathan G. Seidman(4), Christine E. Seidman(4), Alfonso Santiago(3), Chiara Palandri(3), Lorenzo Santini(3), Raffaele Coppini(3), Amanda C. Garfinkel(3), Elisa Passini(3), Maxx Holmes(3)