Melanie R. Power Coombs

Dalhousie University — Canada

Immunology and Microbiology · Life Sciences

20h-index1.1kcitations35works11.52yr avg
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Research Topics

Antimicrobial Peptides and Activities(9), Immune Cell Function and Interaction(4), Protein Hydrolysis and Bioactive Peptides(4), T-cell and B-cell Immunology(3), Antimicrobial Resistance in Staphylococcus(3)

Publications35 total

ALDH1A3 is the switch that determines the balance of ALDH+ and CD24−CD44+ cancer stem cells, EMT-MET, and glucose metabolism in breast cancer
Oncogene·2024· 20 citedOpen Access
Phloridzin Docosahexaenoate, an Omega-3 Fatty Acid Ester of a Flavonoid Precursor, Inhibits Angiogenesis by Suppressing Endothelial Cell Proliferation, Migration, and Differentiation
Biomolecules·2024· 3 citedOpen Access
Phloridzin Docosahexaenoate Inhibits Spheroid Formation by Breast Cancer Stem Cells and Exhibits Cytotoxic Effects against Paclitaxel-Resistant Triple Negative Breast Cancer Cells
International Journal of Molecular Sciences·2023· 9 citedOpen Access
Editorial: Immune Modulation by Flavonoids
Frontiers in Immunology·2022· 21 citedOpen Access
Regulation of macrophage-associated inflammatory responses by species-specific lactoferricin peptides
Frontiers in Bioscience-Landmark·2022· 14 citedOpen Access
The Prostaglandin E2 Pathway and Breast Cancer Stem Cells: Evidence of Increased Signaling and Potential Targeting
Frontiers in Oncology·2022· 30 citedOpen Access
Investigating Potential Applications of the Fish Anti-Microbial Peptide Pleurocidin: A Systematic Review
Pharmaceuticals·2021· 21 citedOpen Access
The Acute Phase Protein Hepcidin Is Cytotoxic to Human and Mouse Myeloma Cells
Anticancer Research·2021· 2 citedOpen Access
Review: Examining the Natural Role of Amphibian Antimicrobial Peptide Magainin
Molecules·2020· 63 citedOpen Access
MDA-MB-231 Breast Cancer Cells Resistant to Pleurocidin-Family Lytic Peptides Are Chemosensitive and Exhibit Reduced Tumor-Forming Capacity
Biomolecules·2020· 9 citedOpen Access
Assessing the Impact of Phytochemicals on Immune Checkpoints: Implications for Cancer Immunotherapy
Methods in molecular biology·2020· 2 cited
DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth and functions as a chemosensitizer by promoting S-phase DNA damage
BioMetals·2019· 9 cited
Anticancer Activities of Natural and Synthetic Peptides
Advances in experimental medicine and biology·2019· 105 cited
Thy-1 (CD90) Signaling Preferentially Promotes RORγt Expression and a Th17 Response
Frontiers in Cell and Developmental Biology·2018· 13 citedOpen Access
Thy-1 stimulation of mouse T cells induces a delayed T cell receptor-like signal that results in Ca2+-independent cytotoxicity
Molecular Medicine Reports·2017· 6 citedOpen Access
Docosahexaenoic acid-acylated phloridzin selectively kills mammary carcinoma cells and inhibits metastasis in vitro and in vivo
European Journal of Cancer·2016
Docosahexaenoic acid-acylated phloridzin, a novel polyphenol fatty acid ester derivative, is cytotoxic to breast cancer cells
Carcinogenesis·2016· 24 citedOpen Access
Abstract 4124: Sub-cytotoxic concentrations of a novel polyphenol fatty acid ester derivative arrest breast cancer cell proliferation and metastasis
Cancer Research·2016
Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells
Cancer Letters·2016· 122 cited
Abstract 4493: Ironing out breast cancer: investigation of a novel iron chelator
Cancer Research·2015
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Frequent Co-authors

David W. Hoskin(26), Wasundara Fernando(7), Ashley L. Hilchie(5), Suzanne J. Furlong(5), H.P. Vasantha Rupasinghe(5), Ofer Levy(4), David Conrad(4), Anna L. Greenshields(4), Carolyn D. Doucette(3), Katelyn A. M. McMillan(3), Paola Marcato(3), Leighanne C. Gallington(2), Michaël Otto(2), Laurence Madera(2), Kenny Kronforst(2), Olivia L. Walker(2), Margaret L. Dahn(2), Nicholas Forward(2), Robert Liwski(2), Taryn Grant(2)