Ashley L. Hilchie

Acadia University — Canada

Immunology and Microbiology · Life Sciences

16h-index1.8kcitations26works0.02yr avg
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Research Topics

Antimicrobial Peptides and Activities(18), Protein Hydrolysis and Bioactive Peptides(7), Biochemical and Structural Characterization(5), RNA Interference and Gene Delivery(4), Immune Response and Inflammation(3)

Publications26 total

The Acute Phase Protein Hepcidin Is Cytotoxic to Human and Mouse Myeloma Cells
Anticancer Research·2021· 2 citedOpen Access
MDA-MB-231 Breast Cancer Cells Resistant to Pleurocidin-Family Lytic Peptides Are Chemosensitive and Exhibit Reduced Tumor-Forming Capacity
Biomolecules·2020· 9 citedOpen Access
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
Biochimica et Biophysica Acta (BBA) - Biomembranes·2020· 48 cited
Anticancer Activities of Natural and Synthetic Peptides
Advances in experimental medicine and biology·2019· 105 cited
Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides
Cell chemical biology·2017· 64 citedOpen Access
Anticancer activities of bovine and human lactoferricin-derived peptides
Biochemistry and Cell Biology·2016· 86 cited
Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma
Biochimica et Biophysica Acta (BBA) - Biomembranes·2016· 78 citedOpen Access
Enhanced killing of breast cancer cells by a d-amino acid analog of the winter flounder-derived pleurocidin NRC-03
Experimental and Molecular Pathology·2015· 31 cited
High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides
Peptides·2015· 102 citedOpen Access
Requirement of the Pseudomonas aeruginosa CbrA Sensor Kinase for Full Virulence in a Murine Acute Lung Infection Model
Infection and Immunity·2013· 29 citedOpen Access
Immune modulation by multifaceted cationic host defense (antimicrobial) peptides
Nature Chemical Biology·2013· 595 cited
Assessment of Antimicrobial (Host Defense) Peptides as Anti-Cancer Agents
Methods in molecular biology·2013· 12 cited
Generation of a hematologic malignancy-selective membranolytic peptide from the antimicrobial core (RRWQWR) of bovine lactoferricin
Experimental and Molecular Pathology·2013· 44 cited
Host Defence (Antimicrobial) Peptides and Proteins
Encyclopedia of Life Sciences·2013· 3 cited
Innate defence regulator peptide 1018 protects mice in the <i>Pseudomonas aeruginosa</i> acute lung infection model (P4045)
The Journal of Immunology·2013· 1 cited
Hepcidin is cytotoxic to myeloma cells (P1337)
The Journal of Immunology·2013
Pleurocidin-family cationic antimicrobial peptides mediate lysis of multiple myeloma cells and impair the growth of multiple myeloma xenografts
Leukemia & lymphoma/Leukemia and lymphoma·2013· 28 cited
Studies on the anticancer properties of pleurocidins: a preclinical evaluation
Library and Archives Canada (Government of Canada)·2012
Piperine, a dietary phytochemical, inhibits angiogenesis
The Journal of Nutritional Biochemistry·2012· 123 citedOpen Access
Obstacles and Solutions to the Use of Cationic Antimicrobial Peptides in the Treatment of Cancer
ACS symposium series·2012· 2 cited
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Frequent Co-authors

David W. Hoskin(17), Robert E. W. Hancock(11), Evan F. Haney(6), Melanie R. Power Coombs(5), Carolyn D. Doucette(4), Robert Liwski(4), Kelli Wuerth(3), Susan E. Douglas(3), Tyler Zemlak(3), David Conrad(3), Devanand M. Pinto(2), Aleksander Patrzykat(2), Carman A. Giacomantonio(2), Mauricio Arias(2), M. Eric Hyndman(2), Hans J. Vogel(2), Jennifer A. Corcoran(2), Jane L. Watson(1), Anna L. Greenshields(1), Richard Hill(1)