Joanne M. Williamson

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Medicine · Health Sciences

24h-index2.8kcitations38works0.02yr avg
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Research Topics

Microbial Natural Products and Biosynthesis(8), Estrogen and related hormone effects(5), Biochemical Acid Research Studies(4), RNA and protein synthesis mechanisms(3), Carbohydrate Chemistry and Synthesis(3)

Publications38 total

Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments
Bioorganic & Medicinal Chemistry Letters·2007· 19 citedOpen Access
New fungal metabolite geranylgeranyltransferase inhibitors with antifungal activity
Natural Product Research·2005· 14 cited
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity
Bioorganic & Medicinal Chemistry Letters·2005· 34 citedOpen Access
Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy
Bioorganic & Medicinal Chemistry Letters·2005· 45 citedOpen Access
Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism
The Journal of Steroid Biochemistry and Molecular Biology·2004· 23 cited
Citrafungins A and B, Two New Fungal Metabolite Inhibitors of GGTase I with Antifungal Activity.
ChemInform·2004· 2 citedOpen Access
Novel <i>N-</i>Arylpyrazolo[3,2-<i>c</i>]-Based Ligands for the Glucocorticoid Receptor:  Receptor Binding and in Vivo Activity
Journal of Medicinal Chemistry·2004· 66 citedOpen Access
Citrafungins A and B, Two New Fungal Metabolite Inhibitors of GGTase I with Antifungal Activity
Organic Letters·2004· 24 cited
Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes
Diabetes·2002· 800 citedOpen Access
Inhibitors of dihydrodipicolinate reductase, a key enzyme of the diaminopimelate pathway of Mycobacterium tuberculosis
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology·2001· 88 cited
Expression and characterization of protein geranylgeranyltransferase type I from the pathogenic yeast Candida albicans and identification of yeast selective enzyme inhibitors
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology·2000· 19 cited
Efficient syntheses, human and yeast farnesyl-protein transferase inhibitory activities of chaetomellic acids and analogues
Bioorganic & Medicinal Chemistry·2000· 31 cited
Geranylgeranyltransferase I of <i>Candida albicans</i> : Null Mutants or Enzyme Inhibitors Produce Unexpected Phenotypes
Journal of Bacteriology·2000· 43 citedOpen Access
Purification of geranylgeranyltransferase I from Candida albicans and cloning of the CaRAM2 and CaCDC43 genes encoding its subunits
Microbiology·1999· 16 cited
ChemInform Abstract: Sporandol: A Novel Antiparasitic Binaphthalene from Chrysosporium meridarium.
ChemInform·1997
SPORANDOL: A NOVEL ANTIPARASITIC BINAPHTHALENE FROM CHRYSOSPORIUM MERIDARIUM
Bioorganic & Medicinal Chemistry Letters·1997· 14 cited
Potent, non-peptidic oxytocin receptor antagonists from a natural source
Bioorganic & Medicinal Chemistry Letters·1993· 33 cited
Acyl-acyl carrier protein specificity of UDP-GlcNAc acyltransferases from gram-negative bacteria: relationship to lipid A structure
Journal of Bacteriology·1991· 65 citedOpen Access
Variecolin, a sesterterpenoid of novel skeleton from Aspergillus variecolor MF138
The Journal of Organic Chemistry·1991· 64 cited
Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site.
Molecular Pharmacology·1990· 63 cited
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Frequent Co-authors

Theresa M. Kelly(8), Paul Mazur(8), Jerrold M. Liesch(7), Michael Goetz(5), Monica Einstein(5), Lan Ge(5), Shilpa Pandit(5), Ayesha Sitlani(5), Rosemarie Kelly(5), Elizabeth Register(5), Sheo B. Singh(5), Cynthia Bonfiglio(5), Edward Inamine(4), James M. Balkovec(4), Milton L. Hammond(4), James R. Tata(4), Georgianna Harris(4), Joseph C. Santoro(4), Chuanlin Wang(4), Chris M. Thompson(4)