Theresa M. Kelly

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index2.0kcitations40works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(11), Neuropeptides and Animal Physiology(10), Nitric Oxide and Endothelin Effects(6), Glycosylation and Glycoproteins Research(5), Regulation of Appetite and Obesity(4)

Publications40 total

Structure of the insulin receptor in complex with insulin using single-particle cryo-EM analysis
Acta Crystallographica Section A Foundations and Advances·2018Open Access
Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis
Nature·2018· 261 citedOpen Access
Erratum. Engineering Glucose Responsiveness Into Insulin. Diabetes 2018;67:299–308
Diabetes·2018· 4 citedOpen Access
A glucose-responsive insulin therapy protects animals against hypoglycemia
JCI Insight·2018· 40 citedOpen Access
A comparative study of the binding properties, dipeptidyl peptidase‐4 (<scp>DPP</scp>‐4) inhibitory activity and glucose‐lowering efficacy of the <scp>DPP</scp>‐4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice
Endocrinology Diabetes & Metabolism·2017· 87 citedOpen Access
Engineering Glucose Responsiveness Into Insulin
Diabetes·2017· 95 cited
Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors
Bioorganic & Medicinal Chemistry·2016· 17 citedOpen Access
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization
Bioorganic & Medicinal Chemistry·2012· 37 citedOpen Access
Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity
ACS Medicinal Chemistry Letters·2012· 61 citedOpen Access
Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality
ACS Medicinal Chemistry Letters·2011· 43 citedOpen Access
Pyridinesulfonylureas and pyridinesulfonamides as selective bombesin receptor subtype-3 (BRS-3) agonists
Bioorganic & Medicinal Chemistry Letters·2011· 13 citedOpen Access
Antiobesity Effect of MK-5046, a Novel Bombesin Receptor Subtype-3 Agonist
Journal of Pharmacology and Experimental Therapeutics·2010· 49 cited
Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity
ACS Medicinal Chemistry Letters·2010· 65 citedOpen Access
Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists
Bioorganic & Medicinal Chemistry Letters·2010· 16 citedOpen Access
Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
Bioorganic & Medicinal Chemistry Letters·2010· 27 citedOpen Access
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
Bioorganic & Medicinal Chemistry Letters·2010· 29 citedOpen Access
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists
Bioorganic & Medicinal Chemistry Letters·2010· 24 citedOpen Access
Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity
Cell Metabolism·2010· 87 citedOpen Access
New fungal metabolite geranylgeranyltransferase inhibitors with antifungal activity
Natural Product Research·2005· 14 cited
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity
Bioorganic & Medicinal Chemistry Letters·2005· 34 citedOpen Access
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Frequent Co-authors

Ravi P. Nargund(14), Xiao-Ming Guan(11), Yanqing Kan(11), Linus S. Lin(11), Oksana Palyha(11), Joseph M. Metzger(10), Marc L. Reitman(10), Joanne M. Williamson(8), Donald J. Marsh(8), Jasminka Dragovic(7), Alison M. Strack(6), Kenny K. Wong(6), Randy R. Miller(5), Iyassu K. Sebhat(5), Peter R. Guzzo(5), Malcolm MacCoss(5), Giovanna Scapin(4), Ester Carballo‐Jane(4), Shuwen He(4), Jianmei Pang(4)