Donald J. Marsh

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Neuroscience · Life Sciences

39h-index7.5kcitations66works0.02yr avg
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Research Topics

Regulation of Appetite and Obesity(27), Neuropeptides and Animal Physiology(24), Receptor Mechanisms and Signaling(16), Biochemical Analysis and Sensing Techniques(12), Sleep and Wakefulness Research(7)

Publications66 total

Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of Obesity and Diabetes
ACS Medicinal Chemistry Letters·2022· 9 citedOpen Access
Effects of Melanocortin Receptor Activation and Blockade on Ethanol Intake: A Possible Role for the Melanocortin-4 Receptor
UNC Libraries·2020· 1 citedOpen Access
Qualification and application of an in vitro liver model early in pharmaceutical development to help derisk drug-induced liver injury (DILI)
Drug Metabolism and Pharmacokinetics·2019· 1 cited
Development of a neuromedin U–human serum albumin conjugate as a long‐acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide
Journal of Peptide Science·2013· 29 cited
A PEGylated analog of the gut hormone oxyntomodulin with long-lasting antihyperglycemic, insulinotropic and anorexigenic activity
Bioorganic & Medicinal Chemistry·2013· 42 cited
Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release—Potential insight into mechanism of action
Obesity·2013· 28 citedOpen Access
PEGylation of Neuromedin U yields a promising candidate for the treatment of obesity and diabetes
Bioorganic & Medicinal Chemistry·2012· 41 cited
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization
Bioorganic & Medicinal Chemistry·2012· 37 citedOpen Access
The Glucagon Receptor Is Involved in Mediating the Body Weight‐Lowering Effects of Oxyntomodulin
Obesity·2012· 106 citedOpen Access
Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity
ACS Medicinal Chemistry Letters·2012· 61 citedOpen Access
CCDC 841544: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
Optimization of co‐agonism at GLP‐1 and glucagon receptors to safely maximize weight reduction in DIO‐rodents
Biopolymers·2012· 134 cited
CCDC 841543: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality
ACS Medicinal Chemistry Letters·2011· 43 citedOpen Access
Effects of Peripherally Administered Neuromedin U on Energy and Glucose Homeostasis
Endocrinology·2011· 63 citedOpen Access
The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species
Journal of Lipid Research·2011· 35 citedOpen Access
DPP‐IV‐resistant, long‐acting oxyntomodulin derivatives
Journal of Peptide Science·2011· 67 cited
Antiobesity Effect of MK-5046, a Novel Bombesin Receptor Subtype-3 Agonist
Journal of Pharmacology and Experimental Therapeutics·2010· 49 cited
Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity
ACS Medicinal Chemistry Letters·2010· 65 citedOpen Access
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
Bioorganic & Medicinal Chemistry Letters·2010· 29 citedOpen Access
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Frequent Co-authors

Xiao-Ming Guan(16), Alison M. Strack(12), Ravi P. Nargund(11), Joseph M. Metzger(11), Richard D. Palmiter(10), Linus S. Lin(9), Alessandro Pocai(8), Yanqing Kan(8), Theresa M. Kelly(8), Oksana Palyha(8), Marc L. Reitman(8), Hong Yu(7), Zhu Shen(6), Douglas J. MacNeil(6), Lauren P. Shearman(6), Lex H.T. Van der Ploeg(6), Elisabetta Bianchi(6), Antonello Pessi(6), Howard Y. Chen(5), Airu S. Chen(5)