Douglas H. Smith

University of Pennsylvania — United States

Medicine · Health Sciences

102h-index37.3kcitations345works4.12yr avg
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Research Topics

Traumatic Brain Injury and Neurovascular Disturbances(196), Traumatic Brain Injury Research(125), S100 Proteins and Annexins(51), Cardiac Arrest and Resuscitation(34), Automotive and Human Injury Biomechanics(26)

Publications345 total

Increased CD3 Immunoreactive Cells Persist Chronically in the Brain Parenchyma in Association with Focal Cortical Contusion following Experimental TBI
2026Open Access
IN MEMORIAM: Dr. Victoria E. Johnson
Journal of Neurotrauma·2025
Simultaneous Reactive Change in Unmyelinated and Myelinated Axon Segments Following Experimental Diffuse Traumatic Brain Injury.
PubMed·2025
Traumatic brain injury or head impacts from contact sports are associated with tau astrogliopathy
Brain·2025· 3 cited
Chronic traumatic encephalopathy neuropathologic change is associated with higher stage limbic‐predominant age‐related TDP‐43 encephalopathy
Alzheimer s & Dementia·2024Open Access
Pediatric Traumatic Brain Injury and Microvascular Blood-Brain Barrier Pathology
JAMA Network Open·2024· 13 citedOpen Access
No sex difference in the extent of acute mechanical blood–brain barrier disruption after experimental concussion
Acta Neuropathologica·2024Open Access
Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury
Brain·2024· 20 citedOpen Access
Nandrolone Abuse Prior to Head Trauma Mitigates Endoplasmic Reticulum Stress, Mitochondrial Bioenergetic Deficits, and Markers of Neurodegeneration
Molecular Neurobiology·2024· 1 citedOpen Access
B - 57 Examining Symptom Patterns in Anomalous Health Incidents: a Spectral Co-Clustering Analysis Using the Post-Concussion Symptom Scale
Archives of Clinical Neuropsychology·2024
Targeting of nanoparticles to the cerebral vasculature after traumatic brain injury
PLoS ONE·2024· 9 citedOpen Access
Daily quetiapine after severe TBI improves learning and memory
The Journal of Trauma: Injury, Infection, and Critical Care·2024· 1 cited
Sex differences in the extent of acute axonal pathologies after experimental concussion
Acta Neuropathologica·2024· 11 citedOpen Access
256 The Neuropathological Basis of Elevated Serum Neurofilament Light Following Experimental Concussion
Neurosurgery·2024
Dose-Dependent Tranexamic Acid Blunting of Penumbral Leukocyte Mobilization and Blood–Brain Barrier Permeability Following Traumatic Brain Injury: An In Vivo Murine Study
Neurocritical Care·2024· 3 cited
Translating from mice to humans: using preclinical blood-based biomarkers for the prognosis and treatment of traumatic brain injury
2023Open Access
Dose Dependent Tranexamic Acid Blunting of Penumbral Leukocyte Mobilization and Blood Brain Barrier Permeability Following Traumatic Brain Injury: An In-vivo Murine Study
Research Square (Research Square)·2023Open Access
Delayed tranexamic acid after traumatic brain injury impedes learning and memory: Early tranexamic acid is favorable but not in sham animals
The Journal of Trauma: Injury, Infection, and Critical Care·2023· 4 cited
The PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial
Nature Medicine·2023· 112 citedOpen Access
Detection of blood–brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2
Acta Neuropathologica·2023· 17 citedOpen Access
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Frequent Co-authors

Daniel J. Capon(11), David F. Meaney(11), Victoria E. Johnson(9), Tracy K. McIntosh(9), William Stewart(7), John Q. Trojanowski(7), John A. Wolf(4), Xiaohan Chen(4), Timothy J. Gregory(3), Scot A. Marsters(3), David V. Goeddel(3), Ellson Y. Chen(3), Kathryn E. Saatman(3), Aya Jakobovits(3), Deborah E. Dodge(2), Laurence A. Lasky(2), Peter H. Seeburg(2), Steven M. Chamow(2), Randal A. Byrn(2), Jerome E. Groopman(2)