Heling Pan

Shanghai Institute of Organic Chemistry — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index3.0kcitations23works4.72yr avg
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Research Topics

Cell death mechanisms and regulation(9), interferon and immune responses(8), Ubiquitin and proteasome pathways(6), NF-κB Signaling Pathways(4), Cellular transport and secretion(3)

Publications23 total

Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors
Immunity·2026
PARP12-mediated mono-ADP-ribosylation as a checkpoint for necroptosis and apoptosis
Proceedings of the National Academy of Sciences·2025· 3 citedOpen Access
Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis
Nature Communications·2025· 11 citedOpen Access
Necroptosis activates UPR sensors without disrupting their binding with GRP78
Proceedings of the National Academy of Sciences·2021· 46 citedOpen Access
NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
Nature Communications·2021· 49 citedOpen Access
Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1
The Journal of Cell Biology·2021· 16 citedOpen Access
Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners
Nature Communications·2020· 84 citedOpen Access
Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma
Proceedings of the National Academy of Sciences·2020· 80 citedOpen Access
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1
Nature·2019· 260 cited
TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL
Molecular Cell·2019· 131 citedOpen Access
Chaperone-mediated autophagy is involved in the execution of ferroptosis
Proceedings of the National Academy of Sciences·2019· 538 citedOpen Access
Corrigendum: SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination
Genes & Development·2018· 1 citedOpen Access
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
Cell·2018· 445 citedOpen Access
Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
Proceedings of the National Academy of Sciences·2018· 141 citedOpen Access
Necroptosis in development and diseases
Genes & Development·2018· 343 citedOpen Access
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC
Nature Cell Biology·2017· 101 citedOpen Access
SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination
Genes & Development·2017· 61 citedOpen Access
Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival
DSpace@MIT (Massachusetts Institute of Technology)·2011Open Access
Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival
Cell·2011· 213 citedOpen Access
Identification of a small molecule activator of novel PKCs for promoting glucose-dependent insulin secretion
Cell Research·2010· 6 citedOpen Access
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Frequent Co-authors

Junying Yuan(21), Bing Shan(10), Hong Zhu(8), Lihui Qian(6), Ayaz Najafov(5), Yanxia Li(5), Zheming Wu(4), Xiaojuan Lu(4), Dawei Ma(4), Palak Amin(4), Jia Yu(3), Chengyu Zou(3), Lifeng Pan(3), Wanjin Li(3), Ying Li(3), Yang Geng(2), Guowei Wu(2), Dimitry Ofengeim(2), Lauren Mifflin(2), Masanori Naito(2)