Ayaz Najafov

Southwestern Medical Center — United States

Medicine · Health Sciences

28h-index4.2kcitations59works4.02yr avg
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Research Topics

Autophagy in Disease and Therapy(11), Cell death mechanisms and regulation(10), Molecular Biology Techniques and Applications(8), Cellular transport and secretion(5), Ubiquitin and proteasome pathways(5)

Publications59 total

SIGLEC12 mediates plasma membrane rupture during necroptotic cell death
Nature·2025· 4 citedOpen Access
Publisher's Note: ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase
Journal of Cell Science·2022· 1 citedOpen Access
Correction to: Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model
Protein & Cell·2021· 1 citedOpen Access
NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
Nature Communications·2021· 49 citedOpen Access
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model
Protein & Cell·2021· 152 citedOpen Access
ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
Nature Communications·2021· 111 citedOpen Access
RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
Molecular Cell·2020· 39 citedOpen Access
Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model
Nature Communications·2020· 182 citedOpen Access
G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L
UNC Libraries·2020Open Access
Modulating TRADD to restore cellular homeostasis and inhibit apoptosis
Nature·2020· 109 cited
Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3
Cell Death and Disease·2019· 31 citedOpen Access
TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL
Molecular Cell·2019· 131 citedOpen Access
ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner
Cell Death and Differentiation·2018· 29 citedOpen Access
BRAF and AXL oncogenes drive RIPK3 expression loss in cancer
PLoS Biology·2018· 83 citedOpen Access
GECO: gene expression correlation analysis after genetic algorithm-driven deconvolution
Bioinformatics·2018· 6 citedOpen Access
Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
Proceedings of the National Academy of Sciences·2018· 141 citedOpen Access
Necroptosis in development and diseases
Genes & Development·2018· 343 citedOpen Access
Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death
Cell Death and Disease·2018· 29 citedOpen Access
Referee report. For: Oncoyeasti: a web-based application to translate data obtained from Saccharomyces cerevisiae high-throughput drug screens into cancer therapeutics [version 1; referees: 1 approved with reservations]
Faculty of 1000 Research Ltd·2018Open Access
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC
Nature Cell Biology·2017· 101 citedOpen Access
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Frequent Co-authors

Junying Yuan(21), Gerta Hoxhaj(17), Jiefei Geng(11), Bing Shan(11), Hongguang Xia(10), Hong Zhu(9), Dimitry Ofengeim(8), Palak Amin(8), Adnan K. Mookhtiar(6), Heling Pan(5), Mengmeng Zhang(5), Yu Cai(5), Yaoyang Zhang(4), Qiang Yu(4), Daichao Xu(4), Xufeng Cen(4), Qingwei Zhao(4), Slawomir A. Dziedzic(4), Huibing Wang(4), Zheng‐Jiang Zhu(4)