Tom Van Loy

Rega Institute for Medical Research — Belgium

Medicine · Health Sciences

24h-index2.0kcitations110works2.42yr avg
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Research Topics

Chemokine receptors and signaling(33), Neurobiology and Insect Physiology Research(25), Receptor Mechanisms and Signaling(17), Monoclonal and Polyclonal Antibodies Research(14), Immunotherapy and Immune Responses(10)

Publications110 total

Synthesis, structure-activity relationship study and molecular modeling of triazolo[4,5-d]pyrimidines targeting an intracellular allosteric binding site of various chemokine receptors
European Journal of Medicinal Chemistry·2026
Human and viral chemokines differentially modulate G protein signaling, β-arrestin recruitment and chemotaxis mediated by the viral G protein-coupled receptor ORF74
Cell Communication and Signaling·2025Open Access
Selective CXCR4-Targeting Antagonists Derived from LY2510924: [¹⁸F]AlF-NOTA-SC, [¹⁷⁷Lu]Lu-BL02, and [¹⁶¹Tb]Tb-BL02 as a Promising Trio for Precision Imaging and Therapy
Nuclear Medicine and Biology·2025
Synthesis and Evaluation of Phenoxybenzylpiperidinyl Analogues as Agonists of the Chemokine Receptor CCR8
Chemistry & Biodiversity·2025Open Access
Biased antagonism of a series of bicyclic CXCR2 intracellular allosteric modulators
Frontiers in Pharmacology·2025Open Access
Structure-activity relationship study of navarixin analogues as dual CXCR2 and CCR7 antagonists
Bioorganic Chemistry·2025· 2 cited
Indium-111-Labeled Single-Domain Antibody for <i>In Vivo</i> CXCR4 Imaging Using Single-Photon Emission Computed Tomography
Bioconjugate Chemistry·2025· 1 citedOpen Access
Design and application of CCR8 antagonists
Future Medicinal Chemistry·2025Open Access
Selective PET imaging of CXCR4 using the Al18F-labeled antagonist LY2510924
European Journal of Nuclear Medicine and Molecular Imaging·2024· 5 citedOpen Access
High-affinity ELR+ chemokine ligands show G protein bias over β-arrestin recruitment and receptor internalization in CXCR1 signaling
Journal of Biological Chemistry·2024· 3 citedOpen Access
Insight into structural properties of viral G protein‐coupled receptors and their role in the viral infection: IUPHAR Review 41
British Journal of Pharmacology·2024· 9 citedOpen Access
Rigid Macrocycle Metal Complexes as CXCR4 Chemokine Receptor Antagonists: Influence of Ring Size
Pharmaceutics·2024· 1 citedOpen Access
Second generation Al18F-labeled D-amino acid peptide for CXCR4 targeted molecular imaging
Nuclear Medicine and Biology·2024· 3 citedOpen Access
Systematic Assessment of Human CCR7 Signalling Using NanoBRET Biosensors Points towards the Importance of the Cellular Context
Biosensors·2024Open Access
Identification of novel human CC chemokine receptor 8 (CCR8) antagonists via the synthesis of naphthalene amide and sulfonamide isosteres
Bioorganic Chemistry·2024· 4 cited
Systematic assessment of chemokine ligand bias at the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization
Cell Communication and Signaling·2024· 10 citedOpen Access
Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells
Cancer Immunology Immunotherapy·2024· 4 citedOpen Access
Structure-Activity Relationship Study of Navarixin Analogues as Dual Cxcr2 and Ccr7 Antagonists
SSRN Electronic Journal·2024Open Access
<i>trans</i>-IV restriction: a new configuration for metal bis-cyclam complexes as potent CXCR4 inhibitors
Dalton Transactions·2024· 4 citedOpen Access
Synthesis and structure–activity relationship study of phenoxybenzylpiperazine analogues as CCR8 agonists
Bioorganic Chemistry·2023· 1 citedOpen Access
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Frequent Co-authors

Dominique Schols(22), Jozef Vanden Broeck(19), Jeroen Poels(15), Matthias B. Van Hiel(9), Gilbert Vassart(8), Arnold De Loof(7), Hans Peter Vandersmissen(7), Anneleen Van Hout(7), Vanessa Franssens(6), Luc Tritsmans(6), Lieven Stuyver(6), Thomas D’huys(6), Steven De Jonghe(6), Ilse Claeys(5), Gert Simonet(5), Jordi Doijen(5), Ronald J. Nachman(4), Heleen Verlinden(4), Ole Lagatie(4), Herbert Torfs(4)