Luc Tritsmans

Janssen (Belgium) — Belgium

Medicine · Health Sciences

14h-index726citations36works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(11), Cholinesterase and Neurodegenerative Diseases(9), Dementia and Cognitive Impairment Research(8), Polyomavirus and related diseases(8), Full-Duplex Wireless Communications(6)

Publications36 total

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial
Journal of Medicinal Chemistry·2021· 48 citedOpen Access
Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer’s disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study
Alzheimer s Research & Therapy·2020· 98 citedOpen Access
Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: A randomized, double-blind, placebo-controlled study and a two-period extension study
Research Square (Research Square)·2020· 8 citedOpen Access
Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: A randomized, double-blind, placebo-controlled study and a two-period extension study
Research Square (Research Square)·2020Open Access
Relevance of the interplay between amyloid and tau for cognitive impairment in early Alzheimer's disease
Neurobiology of Aging·2019· 38 cited
Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer’s disease: randomized, double-blind, placebo-controlled study
Alzheimer s Research & Therapy·2018· 106 citedOpen Access
Evaluating Potential QT Effects of JNJ‐54861911, a BACE Inhibitor in Single‐ and Multiple‐Ascending Dose Studies, and a Thorough QT Trial With Additional Retrospective Confirmation, Using Concentration‐QTc Analysis
The Journal of Clinical Pharmacology·2018· 9 cited
[P2–211]: AMYLOID‐β42 (Aβ42) DIFFERENTIALLY CORRELATES WITH CSF TOTAL AND HYPERPHOSPHORYLATED TAU IN AN AMYLOID‐POSITIVE VERSUS AMYLOID‐NEGATIVE EARLY PRODROMAL AND ASYMPTOMATIC AT‐RISK FOR AD POPULATION
Alzheimer s & Dementia·2017
BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer’s Disease Markers in Elderly Healthy Participants
Journal of Alzheimer s Disease·2017· 33 citedOpen Access
Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ‐54861911, a potent oral BACE inhibitor
Alzheimer s & Dementia Translational Research & Clinical Interventions·2016· 59 citedOpen Access
P2‐001: A Pharmacodynamic Study (54861911ALZ1008) with a Bace Inhibitor, JNJ‐54861911 in Japanese Asymptomatic Subjects at Risk for Alzheimer's Dementia
Alzheimer s & Dementia·2016
P2‐010: Pharmacocokinetic and Pharmacodynamic Study (54861911ALZ1006) with a Bace Inhibitor, JNJ‐54861911, in Healthy Elderly Japanese Subjects
Alzheimer s & Dementia·2016
P2‐011: Pharmacokinetic/Pharmacodynamic Modeling of CSF AB1‐40 Reduction in an Early Alzheimer's Disease Study of JNJ‐54861911, an Oral Bace1 Inhibitor
Alzheimer s & Dementia·2016Open Access
O1‐10‐05: Pharmacodynamics of the Oral Bace Inhibitor JNJ‐54861911 in Early Alzheimer's Disease
Alzheimer s & Dementia·2016· 4 cited
Characterization of Rabbit Antibodies Against the Immunogenic JC Polyomavirus Peptide JCPyV_VP2_167-15mer
Viral Immunology·2015· 1 cited
JC Virus Quasispecies Analysis Reveals a Complex Viral Population Underlying Progressive Multifocal Leukoencephalopathy and Supports Viral Dissemination via the Hematogenous Route
Journal of Virology·2014· 61 citedOpen Access
Antibodies reacting with JCPyV_VP2 _167-15mer as a novel serological marker for JC polyomavirus infection
Virology Journal·2014· 10 citedOpen Access
Viral miRNAs in plasma and urine divulge JC polyomavirus infection
Virology Journal·2014· 42 citedOpen Access
Circulating human microRNAs are not linked to JC polyomavirus serology or urinary viral load in healthy subjects
Virology Journal·2014· 21 citedOpen Access
The miRNA world of polyomaviruses
Virology Journal·2013· 47 citedOpen Access
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Frequent Co-authors

Johannes Streffer(13), Luc Van Nueten(13), Maarten Timmers(10), Ina Tesseur(9), Sebastiaan Engelborghs(9), Alberto Russu(8), Lieven Stuyver(8), Tom Van Loy(6), Ole Lagatie(6), Jennifer Bogert(5), Bianca Van Broeck(5), Gilbert Clincke(5), Pascale Smekens(4), Merçé Boada(4), Luc Janssens(4), Yushin Tominaga(3), Hiroko Shimizu(3), Ayako Shiraishi(3), Anne Börjesson‐Hanson(3), Jorge Matías‐Guiu(3)