Karen Keeshan

University of Glasgow — United Kingdom

Medicine · Health Sciences

29h-index3.0kcitations91works0.32yr avg
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Research Topics

Acute Myeloid Leukemia Research(37), Ubiquitin and proteasome pathways(16), Endoplasmic Reticulum Stress and Disease(16), Protein Degradation and Inhibitors(14), Retinoids in leukemia and cellular processes(11)

Publications90 total

Fetal defense against leukemia: a developmental shield
Blood·2026Open Access
Inducing TRIB2 Targeted Protein Degradation to Reverse Chemoresistance in Acute Myeloid Leukaemia
2025Open Access
Paediatric bone marrow mesenchymal stem cells support acute myeloid leukaemia cell survival and enhance chemoresistance via contact‐independent mechanism
British Journal of Haematology·2024· 1 citedOpen Access
The long non-coding RNA <i>FAM30A</i> regulates the Musashi2-RUNX1 axis and is required for LSC function in AML cells
2024Open Access
KMT2A-MLLT3-Induced Leukaemia Changes During Ontogenic Stages
EMJ Hematology·2024Open Access
Caspase-resistant ROCK1 expression prolongs survival of <i>Eµ-Myc</i> B cell lymphoma mice
Disease Models & Mechanisms·2024· 1 citedOpen Access
Caspase-resistant ROCK1 expression prolongs survival of <i>Eµ-Myc</i> B cell lymphoma mice
2024Open Access
MLL-AF9-Induced Leukaemia Changes during Ontogenic Stages
Blood·2023Open Access
Cover 2: Editorial Board
Experimental Hematology·2023Open Access
Cover 2: Editorial Board
Experimental Hematology·2023Open Access
Nanobodies identify an activated state of the TRIB2 pseudokinase
Structure·2022· 11 citedOpen Access
Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment
Cancer Immunology Immunotherapy·2022· 16 citedOpen Access
Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness
Blood Advances·2022· 23 citedOpen Access
Detecting endogenous TRIB2 protein expression by flow cytometry and Western blotting
Methods in enzymology on CD-ROM/Methods in enzymology·2022· 1 citedOpen Access
Structure vs. Function of TRIB1—Myeloid Neoplasms and Beyond
Cancers·2021· 19 citedOpen Access
Insights into the molecular profiles of adult and paediatric acute myeloid leukaemia
Molecular Oncology·2021· 48 citedOpen Access
BRD4-mediated repression of p53 is a target for combination therapy in AML
Nature Communications·2021· 74 citedOpen Access
Superenhancing AML with Trib1
Blood·2021· 1 citedOpen Access
Pharmacological impact of FLT3 mutations on receptor activity and responsiveness to tyrosine kinase inhibitors
Biochemical Pharmacology·2020· 21 citedOpen Access
A Synthetic Lethal Approach to Eradicate AML Via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors
Blood·2020· 1 citedOpen Access
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Frequent Co-authors

Warren S. Pear(8), Clare M. O’Connor(8), Ruaidhrı́ J. Carmody(8), Olga Shestova(6), Mara Salomè(6), Lanwei Xu(5), Brenda Gibson(5), Patrick A. Eyers(4), Evgenia Sarrou(4), Sharon L. McKenna(4), Thomas G. Cotter(4), Loveena Rishi(4), Kai Ling Liang(4), Bas J. Wouters(3), Ivan Maillard(3), Peter J.M. Valk(3), Shahzya Chaudhury(3), Domenico Somma(3), Patrick A. Kiely(3), Fiona Lohan(3)