Lanwei Xu

Shandong Provincial Hospital — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index6.7kcitations52works0.52yr avg
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Research Topics

Developmental Biology and Gene Regulation(17), Cancer-related gene regulation(13), Epigenetics and DNA Methylation(10), Chronic Myeloid Leukemia Treatments(8), Acute Myeloid Leukemia Research(7)

Publications52 total

Targeting IRAK4 mitigates osteoarthritis by preserving mitochondrial homeostasis and suppressing MAPK/NF-κB-mediated inflammation
2025Open Access
miR-1343-3p, mediated by LncRNA ASMTL-AS1, induces ferroptosis in osteosarcoma progression by targeting TYRO3
Gene·2025· 1 cited
The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade
Cell Reports·2023· 11 citedOpen Access
The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR <sup>+</sup> CD8 <sup>+</sup> effector state and its deletion improves checkpoint blockade
2023Open Access
Trib1 Inhibition Promotes the Klr Effector State and Augments Checkpoint Blockade to Enhance T Cell Function during T Cell Exhaustion
Blood·2022
Trib1 regulates T cell differentiation during chronic infection by restraining the effector program
The Journal of Experimental Medicine·2020· 30 citedOpen Access
TooManyCells identifies and visualizes relationships of single-cell clades
Nature Methods·2020· 95 citedOpen Access
Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program
Blood·2019· 36 citedOpen Access
TooManyCells identifies and visualizes relationships of single-cell clades
2019· 16 cited
MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia
Science Signaling·2017· 19 citedOpen Access
High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia
Blood·2016· 35 citedOpen Access
Modular domains within a super enhancer determine drug resistance in T-cell acute lymphoblastic leukemia
Experimental Hematology·2016· 2 cited
Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL
PLoS ONE·2016· 18 citedOpen Access
Modular Domains within a Super Enhancer Determine Drug Resistance in Leukemia
Blood·2015· 3 cited
Abstract 3938: MafB and ETS2 potentiate Notch signaling in T-ALL
Cancer Research·2015· 1 cited
The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells
Genes & Development·2014· 64 citedOpen Access
Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells
Blood·2012· 50 citedOpen Access
Notch Ankyrin Repeat Domain Variation Influences Leukemogenesis and Myc Transactivation
PLoS ONE·2011· 15 citedOpen Access
Identification of Flt3+CD150− myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential
Blood·2011· 25 citedOpen Access
Critical Functions for Notch Dimerization In T Cell Transformation.
Blood·2010
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Frequent Co-authors

Warren S. Pear(45), Jon C. Aster(23), Olga Shestova(15), Ivan Maillard(10), Fredrick G. Karnell(9), Stephen C. Blacklow(9), Avinash Bhandoola(8), Robert B. Faryabi(8), John C. Pui(7), David Allman(7), Yiping He(7), Karen Keeshan(6), Mark Y. Chiang(6), Jelena Petrovic(6), Phyllis A. Gimotty(5), Kelly Rome(5), Sonia Bakkour(4), Juli P. Miller(4), Arivazhagan Sambandam(4), Hong Sai(4)