Ledong Wan

State University of New York — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.5kcitations40works15.52yr avg
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Research Topics

RNA modifications and cancer(26), RNA Research and Splicing(15), Cancer-related gene regulation(10), Cancer-related molecular mechanisms research(5), Epigenetics and DNA Methylation(4)

Publications40 total

Splice-switching ASOs targeting the AURKA 5′ UTR collapse an SRSF1-AURKA-MYC oncogenic circuit in pancreatic cancer
Molecular Cell·2025
Interpretable multimodal deep learning improves postoperative risk stratification in intrahepatic cholangiocarcinoma in multicentre cohorts
npj Digital Medicine·2025Open Access
Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS<sup>G12D</sup>-Mediated Pancreatic Cancer
2025Open Access
MYC-Driven Activation of USP39 Enhances SRSF1 Stability and Promotes PDAC Progression
2025Open Access
Splice-switching ASOs targeting an Alu-derived exon in the <i>AURKA</i> 5’UTR collapse an SRSF1-AURKA-MYC oncogenic circuit in pancreatic cancer
2025Open Access
Splicing factor RBM10 loss fuels thyroid cancer metastasis
The Journal of Experimental Medicine·2025Open Access
Data from Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer
2024Open Access
Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer
2024Open Access
Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer
2024Open Access
Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma
Nature Genetics·2024· 10 citedOpen Access
Screening Splice-Switching Antisense Oligonucleotides in Pancreas-Cancer Organoids
Nucleic Acid Therapeutics·2024· 14 citedOpen Access
Abstract 5517: Chronic stress causes metastasis via neutrophil-mediated changes to the microenvironment
Cancer Research·2024
Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment
Cancer Cell·2024· 193 citedOpen Access
Abstract C093: Dysregulated spliceosomal components promote pancreatic cancer progression
Cancer Research·2024
RNA Splicing in Cancer and Targeted Therapies
Genes·2023· 1 citedOpen Access
Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS&lt;sup&gt;G12D&lt;/sup&gt;-Mediated Pancreatic Cancer
2023Open Access
Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS&lt;sup&gt;G12D&lt;/sup&gt;-Mediated Pancreatic Cancer
2023Open Access
Data from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS&lt;sup&gt;G12D&lt;/sup&gt;-Mediated Pancreatic Cancer
2023Open Access
Data from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS&lt;sup&gt;G12D&lt;/sup&gt;-Mediated Pancreatic Cancer
2023Open Access
Data from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS&lt;sup&gt;G12D&lt;/sup&gt;-Mediated Pancreatic Cancer
2023· 2 citedOpen Access
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Frequent Co-authors

Adrian R. Krainer(18), Mohammad Alinoor Rahman(16), Youngkyu Park(16), David A. Tuveson(16), Kuan‐Ting Lin(15), Zhikai Wang(15), Yuma Ishigami(14), John E. Wilkinson(13), Mads A. Jensen(12), Maode Lai(9), Alexander J. Kral(6), Enping Xu(5), Honghe Zhang(5), Xue‐Yan He(4), Christopher R. Vakoc(4), Mikala Egeblad(4), Dandan Zhang(4), Dan Yu(4), Jianlu Kong(3), Yihua Wu(3)