Pablo Gaínza

Boston Latin Academy — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index2.5kcitations52works11.52yr avg
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Research Topics

Protein Structure and Dynamics(17), Monoclonal and Polyclonal Antibodies Research(14), RNA and protein synthesis mechanisms(8), CAR-T cell therapy research(7), Computational Drug Discovery Methods(6)

Publications52 total

Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry
Nature Structural & Molecular Biology·2026· 2 citedOpen Access
A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation
Nature Communications·2025· 1 citedOpen Access
Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition
Science·2025· 43 cited
Humanized Caffeine-Inducible Systems for Controlling Cellular Functions
2025· 1 citedOpen Access
Machine learning to predict de novo protein–protein interactions
Trends in biotechnology·2025· 7 citedOpen Access
Molecular surface mimicry enables CRBN to target G3BP2 for degradation
2025· 2 citedOpen Access
Progesterone-bound DB3 Fab in complex with computationally designed DBPro1156_2 protein binder
EMPIAR dataset·2025Open Access
Targeting protein–ligand neosurfaces with a generalizable deep learning tool
Nature·2025· 51 citedOpen Access
Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs
Proceedings of the National Academy of Sciences·2024· 11 citedOpen Access
Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition
2024· 17 citedOpen Access
Targeting protein-ligand neosurfaces using a generalizable deep learning approach
2024· 2 citedOpen Access
A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno‐Stimulating Effects
Small·2024Open Access
Rules and mechanisms governing G protein coupling selectivity of GPCRs
Cell Reports·2023· 75 citedOpen Access
From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation
The Annual Review of Pharmacology and Toxicology·2023· 133 citedOpen Access
Rational Design of Chemically Controlled Antibodies and Protein Therapeutics
ACS Chemical Biology·2023· 17 citedOpen Access
De novo design of protein interactions with learned surface fingerprints
Nature·2023· 202 citedOpen Access
Rational design of chemically controlled antibodies and protein therapeutics
2022· 1 citedOpen Access
<i>De novo</i> design of site-specific protein interactions with learned surface fingerprints
2022· 6 citedOpen Access
Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus
PLoS Computational Biology·2022· 14 citedOpen Access
A rational blueprint for the design of chemically-controlled protein switches
Nature Communications·2021· 38 citedOpen Access
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Frequent Co-authors

Bruno E. Correia(25), Bruce R. Donald(12), Sandrine Georgeon(11), Sailan Shui(10), Leo Scheller(10), Michael M. Bronstein(8), Stéphane Rosset(8), Freyr Sverrisson(7), Simon Friedensohn(6), Lucia Bonati(6), Sai T. Reddy(6), Anthony Marchand(6), Jaume Bonet(6), Bernhard Fasching(6), R.D. Bunker(6), Sharon A. Townson(6), Stephen Buckley(5), Martin Pačesa(5), Elisabetta Cribioli(5), Sabrina S. Vollers(5)