Martin Pačesa

SIB Swiss Institute of Bioinformatics — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index1.9kcitations60works30.02yr avg
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Research Topics

CRISPR and Genetic Engineering(22), RNA and protein synthesis mechanisms(14), Protein Structure and Dynamics(8), Advanced biosensing and bioanalysis techniques(8), Genomics and Chromatin Dynamics(8)

Publications60 total

Molecular basis for anti-jumbo phage immunity by AVAST type 5
Molecular Cell·2026Open Access
Leveraging protein representations to explore uncharted fold spaces with generative models
2025Open Access
Leveraging protein representations to explore uncharted fold spaces with generative models
2025Open Access
Structures of a synthetic antibody selected against and bound to the C‐terminal domain of <i>Clostridium perfringens</i> enterotoxin
Protein Science·2025Open Access
One-shot design of functional protein binders with BindCraft
Nature·2025· 82 citedOpen Access
Design of highly functional genome editors by modelling CRISPR–Cas sequences
Nature·2025· 45 citedOpen Access
Molecular basis for anti-jumbo phage immunity by AVAST Type 5
2025· 2 citedOpen Access
SpCas9 with computationally designed SpCas9_b10 binder
EMPIAR dataset·2025Open Access
CryoEM structure of a synthetic antibody, COP-2, in complex with the C-terminal domain of Clostridium perfringens Enterotoxin
EMPIAR dataset·2025Open Access
Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition
2025· 11 citedOpen Access
Custom CRISPR–Cas9 PAM variants via scalable engineering and machine learning
Nature·2025· 38 citedOpen Access
Boltzdesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design
2025· 19 citedOpen Access
Progesterone-bound DB3 Fab in complex with computationally designed DBPro1156_2 protein binder
EMPIAR dataset·2025Open Access
Cysteine tRNA ligase homodimer
EMPIAR dataset·2025Open Access
Uncharacterized Q8U0N8 protein from Pyrococcus furiosus
EMPIAR dataset·2025Open Access
Targeting protein–ligand neosurfaces with a generalizable deep learning tool
Nature·2025· 51 citedOpen Access
BindCraft: one-shot design of functional protein binders
2024· 95 citedOpen Access
Computational design of soluble and functional membrane protein analogues
Nature·2024· 100 citedOpen Access
Design of highly functional genome editors by modeling the universe of CRISPR-Cas sequences
2024· 82 citedOpen Access
Targeting protein-ligand neosurfaces using a generalizable deep learning approach
2024· 2 citedOpen Access
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Frequent Co-authors

Martin Jínek(21), Bruno E. Correia(16), Sandrine Georgeon(14), Luuk Loeff(10), Irma Querques(10), Marta Sawicka(10), Casper A. Goverde(8), Sergey Ovchinnikov(8), Stephen Buckley(7), Peter Cameron(7), Muckenfuss LM(7), Joseph Schmidt(6), Pablo Gaínza(5), Michael M. Bronstein(5), Paul D. Donohoue(5), Rachel A. Silverstein(5), Benjamin P. Kleinstiver(5), Anthony Marchand(4), Stéphane Rosset(4), L Dornfeld(4)