Atsushi Shimohata

Nippon Medical School — Japan

Medicine · Health Sciences

13h-index814citations21works0.02yr avg
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Research Topics

Down syndrome and intellectual disability research(8), Genetics and Neurodevelopmental Disorders(8), Neuroscience and Neuropharmacology Research(4), Autism Spectrum Disorder Research(3), Retinal Development and Disorders(3)

Publications21 total

The intracellular C-terminal domain of mGluR6 contains ER retention motifs
Molecular and Cellular Neuroscience·2023· 1 cited
CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate
Scientific Reports·2022· 16 citedOpen Access
CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate
2021· 1 citedOpen Access
The C‐terminal domain is required for mGluR6 cell‐surface localization
The FASEB Journal·2021
Involvement of the C‐terminal domain in cell surface localization and G‐protein coupling of mGluR6
Journal of Neurochemistry·2020· 8 cited
Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABAB receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice
Scientific Reports·2020· 12 citedOpen Access
A recurrent <i>PJA1</i> variant in trigonocephaly and neurodevelopmental disorders
Annals of Clinical and Translational Neurology·2020· 28 citedOpen Access
Involvement of the C-terminal domain in cell surface expression and G-protein coupling of mGluR6
2020
Perturbation of the immune cells and prenatal neurogenesis by the triplication of the <i>Erg</i> gene in mouse models of Down syndrome
Brain Pathology·2019· 11 citedOpen Access
Impaired cortico-striatal excitatory transmission triggers epilepsy
Nature Communications·2019· 117 citedOpen Access
Impairments in social novelty recognition and spatial memory in mice with conditional deletion of Scn1a in parvalbumin-expressing cells
Neurobiology of Disease·2018· 49 citedOpen Access
DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures
Neurobiology of Disease·2017· 56 citedOpen Access
Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency
Human Molecular Genetics·2017· 37 citedOpen Access
Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism
Experimental Neurology·2017· 21 cited
Brain ventriculomegaly in Down syndrome mice is caused by <i>Pcp4</i> dose-dependent cilia dysfunction.
Human Molecular Genetics·2017· 38 citedOpen Access
Enlarged Brain Ventricles and Impaired Neurogenesis in the Ts1Cje and Ts2Cje Mouse Models of Down Syndrome
Cerebral Cortex·2009· 109 citedOpen Access
Increased lipid peroxidation in Down’s syndrome mouse models
Journal of Neurochemistry·2009· 68 citedOpen Access
DSCAM Deficiency Causes Loss of Pre-Inspiratory Neuron Synchroneity and Perinatal Death
Journal of Neuroscience·2009· 39 citedOpen Access
Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome
Human Molecular Genetics·2006· 117 citedOpen Access
Pseudomonas aeruginosa under Phosphorus-Poor Culture Conditions: Phospholipid-Poor Bacterial Membranes, and Susceptibility to Antibacterial Chemicals, High Temperature and Low pH.
Microbes and Environments·2002· 2 citedOpen Access
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Frequent Co-authors

Kazuhiro Yamakawa(15), Kenji Amano(11), Matthieu Raveau(8), Haruhiko Sago(7), Hiroyuki Miyamoto(6), Tetsuya Tatsukawa(6), Ikuo Ogiwara(6), Toshimitsu Suzuki(5), Takumi Akagi(5), Keiichi Ishihara(5), Emi Mazaki(4), Dilip Rai(4), Makoto Kaneda(4), Shigeyoshi Itohara(3), Charles J. Epstein(3), Genki Sudo(3), Iori Ohmori(3), Shinichi Hirose(3), Sunao Kaneko(3), Yushi Inoue(3)