Takumi Akagi

Nippon Medical School — Japan

Neuroscience · Life Sciences

27h-index3.8kcitations54works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(16), Alzheimer's disease research and treatments(11), Prion Diseases and Protein Misfolding(6), Cellular transport and secretion(5), Retinal Development and Disorders(5)

Publications54 total

Impaired cardiac non-neuronal acetylcholine synthesis triggers mitochondrial dysfunction with the loss of nicotinic receptor-mediated calcium handling, causing the failing heart
Clinical Science·2025Open Access
The intracellular C-terminal domain of mGluR6 contains ER retention motifs
Molecular and Cellular Neuroscience·2023· 1 cited
Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation
iScience·2022· 9 citedOpen Access
The C‐terminal domain is required for mGluR6 cell‐surface localization
The FASEB Journal·2021
Involvement of the C‐terminal domain in cell surface localization and G‐protein coupling of mGluR6
Journal of Neurochemistry·2020· 8 cited
Involvement of the C-terminal domain in cell surface expression and G-protein coupling of mGluR6
2020
Calcium-dependent activator protein for secretion 2 (CADPS2) deficiency causes abnormal synapse development in hippocampal mossy fiber terminals
Neuroscience Letters·2018· 7 cited
Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning
Neuroscience Research·2018· 28 cited
Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus
Acta Neuropathologica Communications·2017· 17 citedOpen Access
Novel channel-mediated choline transport in cholinergic neurons of the mouse retina
Journal of Neurophysiology·2017· 9 citedOpen Access
The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination
PLoS ONE·2017· 20 citedOpen Access
シナプス可塑性の年齢依存性変化はマウス海馬におけるタウのオリゴマー化を増強する【JST・京大機械翻訳】
2017
Analysis of molecular mechanisms controlling the polarized targeting of metabotropic glutamate receptor type 6
The Journal of Physiological Sciences·2017Open Access
Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments
PLoS ONE·2016· 18 citedOpen Access
ScaleS: an optical clearing palette for biological imaging
Nature Neuroscience·2015· 598 cited
FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis
Acta Neuropathologica Communications·2015· 109 citedOpen Access
l-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation
Journal of Biological Chemistry·2015· 112 citedOpen Access
Table of Contents
American Journal Of Pathology·2015Open Access
Autophagy-Related Protein 7 Deficiency in Amyloid β (Aβ) Precursor Protein Transgenic Mice Decreases Aβ in the Multivesicular Bodies and Induces Aβ Accumulation in the Golgi
American Journal Of Pathology·2014· 94 citedOpen Access
P1‐076: MECHANISMS OF AUTOPHAGY‐MEDIATED AB SECRETION
Alzheimer s & Dementia·2014· 1 cited
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Frequent Co-authors

Tsutomu Hashikawa(27), Makoto Kaneda(9), Akihiko Takashima(8), Miyuki Murayama(7), Nobuyuki Nukina(7), Kentaro Tanemura(6), Atsushi Shimohata(5), Motomasa Tanaka(5), Ikuo Ogiwara(5), Shinji Sato(4), Yuji Yoshiike(4), Koujiro Tohyama(4), Teiichi Furuichi(4), Toshiyuki Ishii(4), Dilip Rai(4), Takashi Saito(3), Takaomi C. Saido(3), Yoshitaka Tatebayashi(3), Tomohiro Miyasaka(3), Dehua Chui(3)