Yuji Yoshiike

National Center for Geriatrics and Gerontology — Japan

Medicine · Health Sciences

20h-index3.4kcitations31works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(24), Cholinesterase and Neurodegenerative Diseases(8), Neuroscience and Neuropharmacology Research(7), Prion Diseases and Protein Misfolding(5), Computational Drug Discovery Methods(3)

Publications31 total

Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups
Nature Communications·2015· 120 citedOpen Access
Nontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies
Scientific Reports·2015· 26 citedOpen Access
P2–048: Phenolic compounds prevent beta‐amyloid‐protein oligomerization and synaptic dysfunction by site‐specific binding
Alzheimer s & Dementia·2013· 1 citedOpen Access
Negatively Charged Gold Nanoparticles Inhibit Alzheimer's Amyloid‐β Fibrillization, Induce Fibril Dissociation, and Mitigate Neurotoxicity
Small·2012· 322 cited
P1‐222: Vitamin A has anti‐oligomerization effects on Aβ <i>in vitro</i>
Alzheimer s & Dementia·2012· 5 cited
Phenolic Compounds Prevent Amyloid β-Protein Oligomerization and Synaptic Dysfunction by Site-specific Binding
Journal of Biological Chemistry·2012· 251 citedOpen Access
Vitamin A has Anti-Oligomerization Effects on Amyloid-β In Vitro
Journal of Alzheimer s Disease·2011· 81 cited
Adaptive responses to alloxan‐induced mild oxidative stress ameliorate certain tauopathy phenotypes
Aging Cell·2011· 11 cited
[GABAergic neurotransmission].
PubMed·2011
Presenilin-Based Transgenic Models of Alzheimer’s Dementia
Neuromethods·2010· 1 cited
Aggregation of Detergent-insoluble Tau Is Involved in Neuronal Loss but Not in Synaptic Loss
Journal of Biological Chemistry·2010· 95 citedOpen Access
P1‐364: Spatiotemporally specific alterations of microtubule‐associated proteins and memory in alloxan‐treated tau transgenic mice
Alzheimer s & Dementia·2010Open Access
GSK-3β Is Required for Memory Reconsolidation in Adult Brain
PLoS ONE·2008· 136 citedOpen Access
Amyloid Oligomer Conformation in a Group of Natively Folded Proteins
PLoS ONE·2008· 69 citedOpen Access
GABAA Receptor-Mediated Acceleration of Aging-Associated Memory Decline in APP/PS1 Mice and Its Pharmacological Treatment by Picrotoxin
PLoS ONE·2008· 103 citedOpen Access
P4‐221: GABA‐linked acceleration of aging‐associated memory decline in APP/PS1 transgenic mouse and its pharmacological treatment by picrotoxin
Alzheimer s & Dementia·2008
Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild‐type human tau
The EMBO Journal·2007· 148 citedOpen Access
Surface Structure of Amyloid-β Fibrils Contributes to Cytotoxicity
Biochemistry·2007· 111 cited
Molecular chaperone‐mediated tau protein metabolism counteracts the formation of granular tau oligomers in human brain
Journal of Neuroscience Research·2007· 89 citedOpen Access
Pore-Forming Proteins Share Structural and Functional Homology with Amyloid Oligomers
NeuroMolecular Medicine·2007· 79 cited
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Frequent Co-authors

Akihiko Takashima(27), Miyuki Murayama(12), Tetsuya Kimura(10), Shunji Yamashita(9), Tatsuya Mizoroki(9), Kenjiro Ono(8), Masahito Yamada(8), Naruhiko Sahara(8), Sumihiro Maeda(6), Kazuhiro Hasegawa(4), Hironobu Naiki(4), Tokuhei Ikeda(4), Junichi Takasaki(4), Takumi Akagi(4), Tetsuya Fukuda(3), Yoshiyuki Soeda(3), Hiroyuki Furudate(3), Yun‐Ru Chen(2), Yuko Saito(2), Tomohiro Miyasaka(2)