Andrew M. Ellisdon

Discovery Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index2.4kcitations56works3.92yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(9), Genetic Neurodegenerative Diseases(8), Mitochondrial Function and Pathology(7), Psoriasis: Treatment and Pathogenesis(6), Cellular transport and secretion(6)

Publications56 total

<i>Helicobacter pylori</i> induces the production of interleukin-37 to promote broad immunosuppression and enhance colonization
Gut Microbes·2026Open Access
Characteristics of T-Cells Expressing IL-37 and Its Receptors in Inflammatory Bowel Disease
International Journal of Molecular Sciences·2026Open Access
Intracellular targeting of a light-activated GPCR elicits spatially selective signalling
2026Open Access
Structure of the lysosomal KICSTOR–GATOR1–SAMTOR nutrient-sensing supercomplex; Lupton, Bayly-Jones et al.
Mendeley Data·2026Open Access
Structure of the lysosomal KICSTOR–GATOR1–SAMTOR nutrient-sensing supercomplex; Lupton, Bayly-Jones et al.
Mendeley Data·2026Open Access
Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex
Cell·2026· 1 citedOpen Access
Hox-C12 coordinates β <sub>2</sub> -adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer
Science Signaling·2025
Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer
Nature Communications·2025· 4 citedOpen Access
Structure of the human TSC:WIPI3 lysosomal recruitment complex
Science Advances·2024· 7 citedOpen Access
LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR
Nature·2024· 33 citedOpen Access
Understanding P-Rex regulation: structural breakthroughs and emerging perspectives
Biochemical Society Transactions·2024· 1 citedOpen Access
Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically ‘actionable’ signalling axis in triple negative breast cancer
2024· 1 citedOpen Access
Thirteen years to get from b to a: one of the neglected isoforms of IL-37 enters the stage
Cellular and Molecular Immunology·2023· 1 citedOpen Access
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
Nature Structural & Molecular Biology·2022· 22 citedOpen Access
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1
Nature Structural & Molecular Biology·2021· 56 cited
Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential
Cell chemical biology·2021· 14 cited
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Nature Communications·2021· 58 citedOpen Access
Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1
Science Signaling·2021· 14 citedOpen Access
The cryo-EM structure of the neurofibromin dimer reveals the molecular basis for von Recklinghausen disease
2021· 3 citedOpen Access
SAGA and SAGA-like SLIK transcriptional coactivators are structurally and biochemically equivalent
Journal of Biological Chemistry·2021· 2 citedOpen Access
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Frequent Co-authors

James C. Whisstock(20), Michelle L. Halls(13), Stephen Bottomley(10), Marcel F. Nold(9), Laura D’Andrea(9), Ralf B. Schittenhelm(9), Christopher J. Lupton(9), Charles Bayly-Jones(8), Claudia A. Nold‐Petry(7), Ina Rudloff(7), Christina M. Lucato(6), Cheng Huang(6), Steven Cho(5), Christina A. Mitchell(5), Hariprasad Venugopal(5), Yong‐Gang Chang(5), Mary C. Pearce(4), Murray Stewart(4), Srgjan Civciristov(4), Elsa A. Marquez(4)