Jeffrey C. Kern

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.0kcitations25works3.02yr avg
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Research Topics

Estrogen and related hormone effects(8), Cancer Immunotherapy and Biomarkers(4), Bioactive Compounds and Antitumor Agents(4), Synthesis and Reactions of Organic Compounds(4), Immunotherapy and Immune Responses(3)

Publications25 total

Preclinical evaluation of MK-8189: A novel phosphodiesterase 10A inhibitor for the treatment of schizophrenia
Journal of Pharmacology and Experimental Therapeutics·2024· 3 citedOpen Access
Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
Journal of Medicinal Chemistry·2023· 37 citedOpen Access
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation
Nature Communications·2021· 116 citedOpen Access
Orexin Receptor 2 (OX2R) in Complex with G Protein and Natural Peptide-Agonist Orexin B (OxB)
2020
Orexin Receptor 2 (OX2R) in Complex with G Protein and Small-Molecule Agonist Compound 1
2020
Development of Anti-CD74 Antibody–Drug Conjugates to Target Glucocorticoids to Immune Cells
Bioconjugate Chemistry·2018· 57 cited
Soluble immune checkpoints CD27, Lag3, PD-L2 and Tim3 in early stage NSCLC patients
European Journal of Cancer·2018· 3 cited
Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs
Bioconjugate Chemistry·2016· 89 cited
Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates
Journal of the American Chemical Society·2016· 136 cited
Antigen presentation by tumor infiltrating B cells influences CD4 T cell phenotype and function in primary lung cancer patient tumors
Journal for ImmunoTherapy of Cancer·2015· 1 citedOpen Access
Activated B cells infiltrate lung cancer (P2201)
The Journal of Immunology·2013
Abstract A5: Characterizing and targeting B cells in lung cancer patients
Clinical Cancer Research·2012
3-(Pyridin-2-yl-ethynyl)benzamide metabotropic glutamate receptor 5 negative allosteric modulators: Hit to lead studies
Bioorganic & Medicinal Chemistry Letters·2010· 4 citedOpen Access
1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2010· 11 citedOpen Access
Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists
Bioorganic & Medicinal Chemistry Letters·2010· 28 citedOpen Access
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: Part II
Bioorganic & Medicinal Chemistry·2009· 25 citedOpen Access
5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators
Bioorganic & Medicinal Chemistry Letters·2009· 11 citedOpen Access
A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation
Bone·2009· 124 cited
Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides
Journal of Medicinal Chemistry·2008· 55 citedOpen Access
1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5′-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators
Bioorganic & Medicinal Chemistry Letters·2008· 7 citedOpen Access
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Frequent Co-authors

Zhiming Zhang(8), Puwen Zhang(8), Richard C. Winneker(8), Yuan Zhu(7), Eugene J. Trybulski(7), Eugene A. Terefenko(7), Jeffrey Cohen(7), Andrew Fensome(6), Matthew R. Yudt(5), Jay Wrobel(5), William Moore(5), Thomas J. Berrodin(4), Linda Liang(3), Philip E. Brandish(3), Mangeng Cheng(3), Guo Feng(3), Juhi Firdos(3), Dennis Gately(3), Anthony Manibusan(3), R. M. Garbaccio(3)