Eugene J. Trybulski

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index1.6kcitations77works0.02yr avg
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Research Topics

Phenothiazines and Benzothiazines Synthesis and Activities(16), Estrogen and related hormone effects(9), Synthesis and pharmacology of benzodiazepine derivatives(9), Synthesis and Biological Evaluation(9), Neurotransmitter Receptor Influence on Behavior(8)

Publications77 total

CCDC 822685: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
Discovery of Novel Selective Norepinephrine Inhibitors: 1-(2-Morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-Dioxides (WYE-114152)
Journal of Medicinal Chemistry·2011· 10 citedOpen Access
CCDC 750454: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
ChemInform Abstract: Heterocyclic Cycloalkanol Ethylamines as Norepinephrine Reuptake Inhibitors.
ChemInform·2010
1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2010· 11 citedOpen Access
Discovery of Novel Selective Norepinephrine Reuptake Inhibitors: 4-[3-Aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3<i>H</i>)-yl]-1-(methylamino)butan-2-ols (WYE-103231)
Journal of Medicinal Chemistry·2010· 17 citedOpen Access
Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists
Bioorganic & Medicinal Chemistry Letters·2010· 28 citedOpen Access
Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter
ACS Medicinal Chemistry Letters·2010· 2 cited
Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 8 citedOpen Access
1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as Potent and Selective Norepinephrine Reuptake Inhibitors
Journal of Medicinal Chemistry·2010· 24 citedOpen Access
Structure–activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores
Bioorganic & Medicinal Chemistry Letters·2010· 9 citedOpen Access
CCDC 737858: Experimental Crystal Structure Determination
The Cambridge Structural Database·2010Open Access
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: Part II
Bioorganic & Medicinal Chemistry·2009· 25 citedOpen Access
5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators
Bioorganic & Medicinal Chemistry Letters·2009· 11 citedOpen Access
Selective Kv1.5 Blockers: Development of (<i>R</i>)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a Potential Treatment for Atrial Arrhythmia
Journal of Medicinal Chemistry·2009· 25 citedOpen Access
Dual acting norepinephrine reuptake inhibitors and 5-HT2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles
Bioorganic & Medicinal Chemistry·2009· 33 citedOpen Access
1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2<i>H</i>-benzimidazol-2-ones: Potent, Selective, and Orally Efficacious Norepinephrine Reuptake Inhibitors
Journal of Medicinal Chemistry·2009· 24 citedOpen Access
Structure–activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 15 citedOpen Access
Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols
Bioorganic & Medicinal Chemistry Letters·2009· 12 citedOpen Access
3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 19 citedOpen Access
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Frequent Co-authors

Darlene C. Deecher(14), Paige E. Mahaney(13), Puwen Zhang(13), Jenifer A. Bray(10), A. T. Vu(9), William Moore(8), Grace H. Johnston(8), Eugene A. Terefenko(8), Richard C. Winneker(7), Jeffrey C. Kern(7), Andrew Fensome(7), R. Ian Fryer(7), Christopher C. Chadwick(6), Douglas C. Harnish(6), Casey C. McComas(6), Scott Cosmi(6), Elizabeth J. Koury(6), Mark A. Ashwell(5), Robert J. Steffan(5), Lisa Nogle(5)