Alan D. Borthwick

Medicine · Health Sciences

28h-index3.1kcitations98works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(24), Carbohydrate Chemistry and Synthesis(13), Neuroendocrine regulation and behavior(13), Biochemical and Molecular Research(12), Synthesis of β-Lactam Compounds(12)

Publications98 total

Functional Alternatives to Alcohol
Nutrients·2022· 7 citedOpen Access
Recent advances in the design of RAR α and RAR β agonists as orally bioavailable drugs. A review
Bioorganic & Medicinal Chemistry·2020· 19 citedOpen Access
<i>Mycobacterium tuberculosis</i> Decaprenylphosphoryl-β-<scp>d</scp>-ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity
Journal of Medicinal Chemistry·2020· 32 cited
Corrigendum to “Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury” [Bioorg. Med. Chem. Lett. 29(8) (2019) 995–1000]
Bioorganic & Medicinal Chemistry Letters·2019Open Access
Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury
Bioorganic & Medicinal Chemistry Letters·2019· 7 citedOpen Access
Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies
Journal of Medicinal Chemistry·2019· 28 citedOpen Access
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist
Bioorganic & Medicinal Chemistry·2017· 9 citedOpen Access
Fluparoxan: A Comprehensive Review of its Discovery, Adrenergic and CNS Activity and Treatment of Cognitive Dysfunction in Central Neurodegenerative Diseases
Mini-Reviews in Medicinal Chemistry·2017· 2 cited
Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening
Journal of Medicinal Chemistry·2016· 30 citedOpen Access
The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits
Journal of Medicinal Chemistry·2015· 42 citedOpen Access
2,5-diketopiperazines in food and beverages: Taste and bioactivity
Critical Reviews in Food Science and Nutrition·2015· 86 cited
Structure-guided optimization of small molecule c-Abl activators
Journal of Computer-Aided Molecular Design·2014· 4 citedOpen Access
Retosiban and Epelsiban: Potent and Selective Orally Available Oxytocin Antagonists
Methods and principles in medicinal chemistry·2013· 9 cited
ChemInform Abstract: 2,5‐Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products
ChemInform·2012· 2 cited
2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products
Chemical Reviews·2012· 833 cited
Pyridyl-2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists: Synthesis, Pharmacokinetics, and In Vivo Potency
Journal of Medicinal Chemistry·2012· 89 citedOpen Access
ChemInform Abstract: The Design of Orally Bioavailable 2,5‐Diketopiperazine Oxytocin Antagonists: From Concept to Clinical Candidate for Premature Labor
ChemInform·2011
Novel RARa agonists for treatment of neurodegenerative disease
2011
The characterization of a novel V1b antagonist lead series
Bioorganic & Medicinal Chemistry Letters·2010· 4 citedOpen Access
Oral Oxytocin Antagonists
Journal of Medicinal Chemistry·2010· 31 citedOpen Access
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Frequent Co-authors

Anne M. Exall(20), Keith Biggadike(13), Robert J. Young(9), Andrew M. Mason(8), Barrie E. Kirk(8), Michael Allen(6), Gordon G. Weingarten(6), Stanley M. Roberts(6), Peter Youds(6), Terry Haley(5), John Liddle(5), Wendy R. Irving(5), Fabrizio Nerozzi(5), Derek Pollard(5), Steve L. Sollis(5), Dave E. Davies(5), Angela Patikis(5), Chuen Chan(5), David Brown(5), Cynthia L. Burns-Kurtis(5)