Anne M. Exall

GlaxoSmithKline (United Kingdom) — United Kingdom

Medicine · Health Sciences

18h-index985citations40works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

HIV/AIDS drug development and treatment(13), Carbohydrate Chemistry and Synthesis(8), Biochemical and Molecular Research(8), Synthesis of β-Lactam Compounds(7), Neuroendocrine regulation and behavior(6)

Publications40 total

Pyridyl-2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists: Synthesis, Pharmacokinetics, and In Vivo Potency
Journal of Medicinal Chemistry·2012· 89 citedOpen Access
The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Bioorganic & Medicinal Chemistry Letters·2011· 13 citedOpen Access
Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
Bioorganic & Medicinal Chemistry Letters·2011· 9 citedOpen Access
The discovery of GSK221149A: a potent and selective oxytocin antagonist. Bioorg Med Chem Lett
2008· 1 cited
The discovery of GSK221149A: A potent and selective oxytocin antagonist
Bioorganic & Medicinal Chemistry Letters·2007· 90 citedOpen Access
CCDC 272988: Experimental Crystal Structure Determination
The Cambridge Structural Database·2007Open Access
2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 3. Synthesis, Pharmacokinetics, and in Vivo Potency
Journal of Medicinal Chemistry·2006· 44 cited
2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 2. Synthesis, Chirality, and Pharmacokinetics
Journal of Medicinal Chemistry·2005· 53 citedOpen Access
2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: identification, stereochemistry and initial SAR
Bioorganic & Medicinal Chemistry Letters·2005· 66 cited
Design and Synthesis of Pyrrolidine-5,5‘-<i>trans-</i>Lactams (5-Oxo-hexahydropyrrolo[3,2-<i>b</i>]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 4. Antiviral Activity and Plasma Stability
Journal of Medicinal Chemistry·2003· 71 citedOpen Access
Pyrrolidine‐5,5‐trans‐lactams as Novel Mechanism‐Based Inhibitors of Human Cytomegalovirus Protease. Part 3. Potency and Plasma Stability.
ChemInform·2002
Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability
Bioorganic & Medicinal Chemistry Letters·2002· 26 citedOpen Access
Design and Synthesis of Pyrrolidine-5,5-<i>trans-</i>lactams (5-Oxohexahydropyrrolo[3,2-<i>b</i>]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 2. Potency and Chirality
Journal of Medicinal Chemistry·2001· 72 citedOpen Access
Stereoselective synthesis of gem-dimethyl-5,5-pyrrolidine-trans-lactam (5-oxo-hexahydropyrrolo[3,2-b]pyrrole)
Tetrahedron Letters·2001· 3 cited
Design and Synthesis of Pyrrolidine-5,5-<i>trans-</i>lactams (5-Oxo-hexahydro-pyrrolo[3,2-<i>b</i>]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 1. The α-Methyl-<i>trans</i>-lactam Template
Journal of Medicinal Chemistry·2000· 46 citedOpen Access
ChemInform Abstract: Stereoselective Synthesis of α‐Methyl and β‐Methyl Pyrrolidine 5,5‐trans‐Lactam (5‐Oxo‐hexahydro‐pyrrolo[3,2‐b]pyrrole) and Stereoselective Alkylation of the Strained Pyrrolidine 5,5‐trans‐Lactam Ring System.
ChemInform·2000
α-メチルおよびβ-メチルピロリジン5,5-trans-ラクタム(5-オキソ-ヘキサヒドロ-ピロロ[3,2-b]ピロール)の立体選択的合成およびひずみを受けたピロリジン5,5-trans-ラクタム環系の立体選択的アルキル化
Synlett·2000
An improved synthesis of the strained pyrrolidine-5,5-translactam ring system
Tetrahedron Letters·1999· 4 cited
ChemInform Abstract: A Short, Convergent Synthesis of Two Chiral Antiviral Agents, (+)‐ Carbocyclic 2′‐Deoxy‐5‐((E)‐2‐Bromovinyl) Uridine and (+)‐Carbocyclic 2′‐Deoxyguanosine.
ChemInform·1996
A short, convergent synthesis of two chiral antiviral agents, (+) carbocyclic 2′-deoxy-5-[(E)-2-bromovinyl] uridine and (+) carbocyclic 2′-deoxyGuanosine
Tetrahedron Letters·1995· 13 cited
page 1 of 2Next →

Frequent Co-authors

Alan D. Borthwick(36), Keith Biggadike(16), Barrie E. Kirk(14), Gordon G. Weingarten(13), Stanley M. Roberts(11), Peter Youds(11), Andrew M. Mason(9), Fabrizio Nerozzi(7), Andrew J. Crame(7), Michael Allen(6), David E. Davies(6), Wendy R. Irving(6), Steve L. Sollis(6), Dave E. Davies(5), Terry Haley(5), Andrew M. K. Pennell(5), Deborah L. Jackson(5), P.M. Woollard(4), David G. Livermore(4), Suzanne Butt(4)