David E. Davies

GlaxoSmithKline (United Kingdom) — United Kingdom

Chemistry · Physical Sciences

11h-index355citations18works0.02yr avg
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Research Topics

Chemical Reaction Mechanisms(3), Synthesis and Biological Evaluation(3), Synthesis of β-Lactam Compounds(3), Asymmetric Synthesis and Catalysis(2), Atrial Fibrillation Management and Outcomes(2)

Publications18 total

The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Bioorganic & Medicinal Chemistry Letters·2011· 13 citedOpen Access
Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
Bioorganic & Medicinal Chemistry Letters·2011· 9 citedOpen Access
A new topical formulation enhances relative diclofenac bioavailability in healthy male subjects
British Journal of Clinical Pharmacology·2011· 38 citedOpen Access
The discovery of GSK221149A: a potent and selective oxytocin antagonist. Bioorg Med Chem Lett
2008· 1 cited
The discovery of GSK221149A: A potent and selective oxytocin antagonist
Bioorganic & Medicinal Chemistry Letters·2007· 90 citedOpen Access
Synthesis of an external beta-turn based on the GLDV motif of cell adhesion proteins
Tetrahedron·2004· 14 cited
Synthesis of an external β-turn based on the GLDV motif of cell adhesion proteins
Tetrahedron Letters·2003· 15 cited
Stereoselective synthesis of gem-dimethyl-5,5-pyrrolidine-trans-lactam (5-oxo-hexahydropyrrolo[3,2-b]pyrrole)
Tetrahedron Letters·2001· 3 cited
ChemInform Abstract: Stereoselective Synthesis of α‐Methyl and β‐Methyl Pyrrolidine 5,5‐trans‐Lactam (5‐Oxo‐hexahydro‐pyrrolo[3,2‐b]pyrrole) and Stereoselective Alkylation of the Strained Pyrrolidine 5,5‐trans‐Lactam Ring System.
ChemInform·2000
Novel renin inhibitors: synthesis of aminostatine and comparison with statine-containing analogues
Journal of the Chemical Society Chemical Communications·1986· 28 cited
On the treatment of migraine. Pharmacokinetic-pharmacodynamic relationships for a programmed release formulation of dihydroergotamine administered orally in the human
Cephalalgia·1983· 2 cited
The cycloaddition of α-nitrosostyrenes to olefins. Investigations of the scope and mechanism of the reaction
Journal of the Chemical Society Perkin Transactions 1·1983· 49 cited
Investigation of the retro-Diels–Alder reaction as a method for the generation of nitroso-olefins
Journal of the Chemical Society Perkin Transactions 1·1983· 14 cited
Competing [4 + 2] and [3 + 2] cycloaddition in the reactions of nucleophilic olefins with ethyl 3-(toluene-p-sulphonylazo)but-2-enoate
Journal of the Chemical Society Perkin Transactions 1·1983· 32 cited
Long-term monitoring of the effects of thymoxamine hydrochloride tablets in the management of patients with Raynaud's disease
Current Medical Research and Opinion·1982· 10 cited
Synthesis of novel fused β-lactams by intramolecular 1,3-dipolar cycloadditions. Part 1. Tricyclic triazole
Journal of the Chemical Society Perkin Transactions 1·1981· 10 cited
AIR EMBOLISM DURING CAESAREAN SECTION
The Medical Journal of Australia·1980· 15 cited
Cycladdition of 1,2,3-benzotriazines to diphenylcyclopropenone
Journal of the Chemical Society Chemical Communications·1980· 12 cited

Frequent Co-authors

Anne M. Exall(6), Alan D. Borthwick(4), Wendy R. Irving(4), Andrew M. Mason(3), T. L. Gilchrist(3), John Liddle(2), Michael Allen(2), David P. Brooks(2), Richard M. Edwards(2), C. Hamlett(2), Gerald P. McCafferty(2), Fabrizio Nerozzi(2), Simon Peace(2), Joanne Philp(2), Derek Pollard(2), Mark Pullen(2), Shaila Shabbir(2), Steve L. Sollis(2), Timothy D. Westfall(2), Pat M. Woollard(2)