Takashi Umehara

Ritsumeikan University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

40h-index4.8kcitations202works3.52yr avg
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Research Topics

Genomics and Chromatin Dynamics(50), Epigenetics and DNA Methylation(49), Cancer-related gene regulation(34), RNA modifications and cancer(30), RNA and protein synthesis mechanisms(25)

Publications202 total

Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Science Advances·2025· 2 citedOpen Access
Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice
PLoS Biology·2025· 1 citedOpen Access
Temperature vaulting: A method for screening of slow- and tight-binding inhibitors that selectively target kinases in their non-native state
European Journal of Medicinal Chemistry·2025· 1 cited
Discovery of potent substrate-type lysine methyltransferase G9a inhibitors for the treatment of sickle cell disease
European Journal of Medicinal Chemistry·2025· 1 cited
Discovery of a novel class NSD2 inhibitor for multiple myeloma with t(4;14)+
Blood Neoplasia·2025· 2 citedOpen Access
Temperature vaulting: A method for screening of slow- and tight-binding inhibitors that selectively target kinases in their non-native state
2025
Temperature Vaulting: A Method for Screening of Slow- and Tight-Binding Inhibitors that Selectively Target Kinases in Their Non-Native State
SSRN Electronic Journal·2025Open Access
Gene-scale <i>in vitro</i> reconstitution reveals histone acetylation directly controls chromatin architecture
2024· 1 citedOpen Access
Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma
Cancer Gene Therapy·2024· 8 citedOpen Access
OA-35 Discovery of a Novel Class MMSET Inhibitor With Specificity for t(4; 14)-Positive Multiple Myeloma
Clinical Lymphoma Myeloma & Leukemia·2024
Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment
Bioorganic & Medicinal Chemistry Letters·2024· 2 citedOpen Access
Efficiency of transcription and translation of cell-free protein synthesis systems in cell-sized lipid vesicles with changing lipid composition determined by fluorescence measurements
Scientific Reports·2024· 11 citedOpen Access
Polycomb-mediated histone modifications and gene regulation
Biochemical Society Transactions·2024· 17 cited
Efficiency of transcription and translation of cell-free protein synthesis systems in cell-sized lipid vesicles with changed lipids
Research Square (Research Square)·2023Open Access
GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain
Proceedings of the National Academy of Sciences·2023· 16 citedOpen Access
Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties
BMC Genomics·2023· 14 citedOpen Access
Epigenetic mechanisms to propagate histone acetylation by p300/CBP
Nature Communications·2023· 55 citedOpen Access
Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin
Molecular Cell·2023· 60 citedOpen Access
Lysine long-chain fatty acylation regulates the TEAD transcription factor
Cell Reports·2023· 10 citedOpen Access
Epigenetic mechanisms to propagate histone acetylation by p300/CBP
2023· 5 citedOpen Access
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Frequent Co-authors

Shigeyuki Yokoyama(32), Mikako Shirouzu(15), Masami Horikoshi(9), Balasundaram Padmanabhan(9), Masatoshi Wakamori(9), Shin Sato(8), Akiko Tanaka(7), Kensaku Sakamoto(7), Hideaki Niwa(7), Yoshihiro Nakamura(6), T. Kigawa(6), Takaho Terada(6), Masaki Kikuchi(6), Minoru Yoshida(5), Shinya Mimasu(4), Keiko Ozato(4), Makoto Inoue(4), Moon Kyoo Jang(3), Kazumi Nakano(3), Satoru Watanabe(3)