Charles E. Whitehurst

Boehringer Ingelheim (United States) — United States

Immunology and Microbiology · Life Sciences

25h-index3.3kcitations44works3.22yr avg
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Research Topics

T-cell and B-cell Immunology(14), Immune Cell Function and Interaction(13), Immune Response and Inflammation(4), Glycosylation and Glycoproteins Research(4), Cytokine Signaling Pathways and Interactions(4)

Publications44 total

Deep representation learning for clustering longitudinal survival data from electronic health records
Nature Communications·2025· 11 citedOpen Access
Label-free detection of prostaglandin transporter (SLCO2A1) function and inhibition: insights by wound healing and TRACT assays
Frontiers in Pharmacology·2024· 4 citedOpen Access
Cooperativity by Low Extracellular pH and Tumor Necrosis Factor α (TNFα) in Ovarian Cancer GPCR1 (OGR1)-dependent Cytokine Production in Airway Smooth Muscle
2024
Deep representation learning for clustering longitudinal survival data from electronic health records
2024· 1 citedOpen Access
Deep representation learning for clustering longitudinal survival data from electronic health records
2024Open Access
Reverse translation approach generates a signature of penetrating fibrosis in Crohn’s disease that is associated with anti-TNF response
Gut·2021· 29 cited
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9
Nature·2020· 213 citedOpen Access
The RESOLUTE consortium: unlocking SLC transporters for drug discovery
Nature Reviews Drug Discovery·2020· 106 cited
Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells
Cell·2019· 199 citedOpen Access
Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy
Cell·2019· 852 citedOpen Access
Single Cell Explorer, collaboration-driven tools to leverage large-scale single cell RNA-seq data
BMC Genomics·2019· 28 citedOpen Access
Sa1895 – Characterization and Modeling of the Creeping Fat that Occurs in Crohn’s Disease
Gastroenterology·2019· 1 cited
Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors
Bioorganic & Medicinal Chemistry Letters·2013· 24 citedOpen Access
Potency switch between CHK1 and MK2: Discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors
Bioorganic & Medicinal Chemistry Letters·2013· 10 citedOpen Access
Application of Affinity Selection-Mass Spectrometry Assays to Purification and Affinity-Based Screening of the Chemokine Receptor CXCR4
Combinatorial Chemistry & High Throughput Screening·2012· 24 cited
STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells
Bioorganic & Medicinal Chemistry·2011· 23 citedOpen Access
Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors
ACS Medicinal Chemistry Letters·2011· 33 citedOpen Access
Expression of Gal4-VP16 and Gal4-DNA binding domain under the control of the T lymphocyte-specific lck proximal promoter in transgenic mice
BMB Reports·2008· 4 citedOpen Access
Affinity Selection-Mass Spectrometry and its Emerging Application to the High Throughput Screening of G Protein-Coupled Receptors
Combinatorial Chemistry & High Throughput Screening·2008· 29 cited
Affinity selection-mass spectrometry screening techniques for small molecule drug discovery
Current Opinion in Chemical Biology·2007· 223 cited
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Frequent Co-authors

Jianzhu Chen(12), T D Geppert(4), Samit Chattopadhyay(4), Chun Jeih Ryu(4), N. Gengozian(4), Xianshu Yang(3), Michael R. Ziebell(3), Brian B. Haines(3), Brian D. Muegge(3), Shanshan Xiong(3), Chin‐Wen Lai(3), Ta‐Chiang Liu(3), Thaddeus S. Stappenbeck(3), Denise Murphy(3), Peter Spacciapoli(3), Cliff C. Cheng(3), Gerald W. Shipps(3), Jiajun Qiu(3), Yao Hu(3), A. Mesut Erzurumluoglu(3)