Ana Paula Arruda

Harvard University — United States

Medicine · Health Sciences

26h-index3.5kcitations54works10.32yr avg
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Research Topics

Adipose Tissue and Metabolism(25), Endoplasmic Reticulum Stress and Disease(18), Mitochondrial Function and Pathology(9), Adipokines, Inflammation, and Metabolic Diseases(9), Pancreatic function and diabetes(8)

Publications54 total

Nutrient-Sensing Nuclear Receptor <i>PPARα</i> Controls Liver Proteostasis
2025Open Access
CoQ imbalance drives reverse electron transport to disrupt liver metabolism
Nature·2025· 16 citedOpen Access
CaMKIIβ Ca2+ptures ER signals to initiate autophagosome biogenesis
Molecular Cell·2025· 2 cited
CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly
2024· 14 citedOpen Access
Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2024· 7 citedOpen Access
Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity
Nature Communications·2024· 32 citedOpen Access
Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets
2024· 2 citedOpen Access
Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis
The EMBO Journal·2024· 9 citedOpen Access
Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity
2023· 3 citedOpen Access
Integration of ER protein quality control mechanisms defines β cell function and ER architecture
Journal of Clinical Investigation·2022· 45 citedOpen Access
Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease
Cold Spring Harbor Perspectives in Biology·2022· 25 citedOpen Access
Regulation of liver subcellular architecture controls metabolic homeostasis
Nature·2022· 117 citedOpen Access
Aberrant Ca <sup>2+</sup> signaling by IP <sub>3</sub> Rs in adipocytes links inflammation to metabolic dysregulation in obesity
Science Signaling·2021· 19 citedOpen Access
Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism
Cell Metabolism·2021· 20 citedOpen Access
Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism
Cell Metabolism·2020· 99 citedOpen Access
High resolution 3D imaging of liver reveals a central role for subcellular architectural organization in metabolism
2020· 9 citedOpen Access
Aberrant Ca <sup>2+</sup> homeostasis in adipocytes links inflammation to metabolic dysregulation in obesity
2020· 4 citedOpen Access
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
DSpace@MIT (Massachusetts Institute of Technology)·2018Open Access
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
Nature Medicine·2018· 213 citedOpen Access
Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity
eLife·2017· 54 citedOpen Access
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Frequent Co-authors

Güneş Parlakgül(17), Gökhan S. Hotamışlıgil(17), Lı́cio A. Velloso(13), Marciane Milanski(12), Leopoldo de Meis(11), Karen Inouye(9), Andressa Coope(9), Denise Pires de Carvalho(8), Ekin Güney(6), Talita Romanatto(6), Erika Cagampan(6), Grace Yankun Lee(6), Scott B. Widenmaier(5), Letícia Martins Ignácio-Souza(5), Renata L. S. Gonçalves(5), Carina Solon(5), Erika Roman(4), Nina Min(4), Yankun G. Lee(4), Benedicte Mengel Pers(3)