Richard D. Taylor

St Bartholomew's Hospital — United Kingdom

Computer Science · Physical Sciences

22h-index8.7kcitations47works0.02yr avg
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Research Topics

Computational Drug Discovery Methods(19), Protein Structure and Dynamics(12), Monoclonal and Polyclonal Antibodies Research(11), Click Chemistry and Applications(6), Pharmacogenetics and Drug Metabolism(4)

Publications46 total

42. Prospective trial investigating interactable nonsurgical neuropathic lower lumbar pain (PSPS type1) using mixed waveform SCS therapy: 2 years clinical data
Neuromodulation Technology at the Neural Interface·2025
Design of Novel Series of Antimalarial PMX Inhibitors with Increased Half-Life via Molecular Property Optimization
ACS Medicinal Chemistry Letters·2023· 5 citedOpen Access
Water Networks in Complexes between Proteins and FDA-Approved Drugs
Journal of Chemical Information and Modeling·2022· 13 citedOpen Access
Open Binding Pose Metadynamics: An Effective Approach for the Ranking of Protein–Ligand Binding Poses
Journal of Chemical Information and Modeling·2022· 38 citedOpen Access
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of <b>UCB7362</b>
Journal of Medicinal Chemistry·2022· 27 citedOpen Access
Water networks in complexes between proteins and FDA-approved drugs
2022Open Access
Water networks in complexes between proteins and FDA-approved drugs
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Rings in Clinical Trials and Drugs: Present and Future
Journal of Medicinal Chemistry·2022· 385 citedOpen Access
Higher Affinity Antibodies Bind With Lower Hydration and Flexibility in Large Scale Simulations
Frontiers in Immunology·2022· 4 citedOpen Access
Rings in Clinical Trials and Drugs: Present and Future - Datasets
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Rings in Clinical Trials and Drugs: Present and Future - Datasets
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
The Chemical Synthesis of Knob Domain Antibody Fragments
ACS Chemical Biology·2021· 12 citedOpen Access
The chemical synthesis of knob domain antibody fragments
2021Open Access
Water molecules at protein–drug interfaces: computational prediction and analysis methods
Chemical Society Reviews·2021· 66 cited
Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR
PLoS Biology·2018· 43 citedOpen Access
CONCEPTION D’ANTICORPS DE NOVO
2017
Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling
Scientific Reports·2017· 42 citedOpen Access
Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping
Scientific Reports·2017· 38 citedOpen Access
Timeline
University of Texas Press eBooks·2016Open Access
Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery
Journal of Medicinal Chemistry·2016· 62 cited
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Frequent Co-authors

Alastair D. G. Lawson(8), Jonathan W. Essex(8), Marcel L. Verdonk(7), Christopher W. Murray(7), Michael J. Hartshorn(4), Malcolm MacCoss(4), Sebastian Kelm(4), Jiye Shi(4), Jason C. Cole(3), Marley L. Samways(3), Delphine Ménard(3), Ion Niculescu‐Duvaz(3), H.P. Dijkstra(3), Dan Niculescu‐Duvaz(3), Bart M. J. M. Suijkerbuijk(3), Alfonso Zambon(3), Arnaud Nourry(3), Lawrence Davies(3), Helen Manne(3), Frank Friedlos(3)