Mark Hochstrasser

Yale University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

77h-index27.7kcitations221works1.02yr avg
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Research Topics

Ubiquitin and proteasome pathways(169), Endoplasmic Reticulum Stress and Disease(67), Autophagy in Disease and Therapy(40), Peptidase Inhibition and Analysis(38), Glycosylation and Glycoproteins Research(32)

Publications217 total

Sumoylation of cyclin and its therapeutic potential for cancer
Animal Cells and Systems·2025Open Access
Deubiquitylases and nucleases in bacterial symbiont-induced cytoplasmic incompatibility
Biochemical Society Transactions·2025· 1 citedOpen Access
AMPK alters proteasome phosphorylation status and prevents persistent proteasome condensates
Genetics·2025· 1 cited
AMPK alters proteasome phosphorylation status and prevents persistent proteasome condensates
2025Open Access
Auto-sumoylation of the yeast Ubc9 E2 SUMO-conjugating enzyme extends cellular lifespan
Nature Communications·2025· 2 citedOpen Access
A cut above: Bacterial deubiquitinases with ubiquitin clippase activity
Molecular Cell·2025· 1 citedOpen Access
Use of a High-Affinity Ubiquitin-Binding Domain to Detect and Purify Ubiquitinated Substrates and Their Interacting Proteins
BIO-PROTOCOL·2025Open Access
Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity
iScience·2024· 2 citedOpen Access
Auto-sumoylation of the Ubc9 E2 SUMO-conjugating Enzyme Extends Cellular Lifespan
2024Open Access
Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1
Scientific Reports·2024· 3 citedOpen Access
Sis2 regulates yeast replicative lifespan in a dose-dependent manner
Nature Communications·2023· 12 citedOpen Access
Species-specific protein–protein interactions govern the humanization of the 20S proteasome in yeast
Genetics·2023· 6 citedOpen Access
Molecular Biology of Cytoplasmic Incompatibility Caused by <i>Wolbachia</i> Endosymbionts
Annual Review of Microbiology·2023· 20 citedOpen Access
Proteasomes: Isolation and Activity Assays
Current Protocols·2023· 3 citedOpen Access
Ectopic RING activity at the ER membrane differentially impacts ERAD protein quality control pathways
Journal of Biological Chemistry·2023· 3 citedOpen Access
Orientia tsutsugamushi OtDUB Is Expressed and Interacts with Adaptor Protein Complexes during Infection
Infection and Immunity·2022· 11 citedOpen Access
Elements of the ERAD ubiquitin ligase Doa10 regulating sequential poly-ubiquitylation of its targets
iScience·2022· 14 citedOpen Access
A versatile new tool derived from a bacterial deubiquitylase to detect and purify ubiquitylated substrates and their interacting proteins
PLoS Biology·2022· 17 citedOpen Access
OtDUB from the Human Pathogen <i>Orientia tsutsugamushi</i> Modulates Host Membrane Trafficking by Multiple Mechanisms
Molecular and Cellular Biology·2022· 8 citedOpen Access
Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeast
2022· 1 citedOpen Access
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Frequent Co-authors

Alexander Y. Amerik(4), Shyr‐Jiann Li(4), Tommer Ravid(3), Robert J. Tomko(3), Stefan G. Kreft(3), M Funakoshi(3), Oliver Kerscher(2), Yang Xie(2), Robert Swanson(2), John F. Beckmann(2), Ping Chen(2), Phoebe Johnson(2), Mary B. Kroetz(2), Andrew Emili(2), Feroz R. Papa(2), Sowmya Swaminathan(2), David R. Mathog(2), Yosef Gruenbaum(2), Harald Saumweber(2), John W. Sedat(2)