David W. Colby

Neoleukin Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index3.4kcitations33works0.02yr avg
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Research Topics

Prion Diseases and Protein Misfolding(17), Alzheimer's disease research and treatments(9), Genetic Neurodegenerative Diseases(7), Monoclonal and Polyclonal Antibodies Research(7), Fungal and yeast genetics research(6)

Publications33 total

Correction to Conformational Features of Tau Fibrils from Alzheimer’s Disease Brain Are Faithfully Propagated by Unmodified Recombinant Protein
Biochemistry·2024Open Access
953 Identification of a human IFNα2b variant active in mice and its use in a new class of targeted and conditional IFNα therapeutics
Regular and Young Investigator Award Abstracts·2024Open Access
Inert and seed-competent tau monomers suggest structural origins of aggregation
eLife·2018· 233 citedOpen Access
Author response: Inert and seed-competent tau monomers suggest structural origins of aggregation
2018· 5 citedOpen Access
Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells
Biomaterials Science·2018· 41 cited
The N-terminus of the prion protein is a toxic effector regulated by the C-terminus
eLife·2017· 84 citedOpen Access
Author response: The N-terminus of the prion protein is a toxic effector regulated by the C-terminus
2017· 1 citedOpen Access
Chemical Engineering Senior Laboratory: The University of Delaware
Chemical Engineering Education·2016
Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation
FEBS Letters·2015· 21 citedOpen Access
Conformation-Dependent Epitopes Recognized by Prion Protein Antibodies Probed Using Mutational Scanning and Deep Sequencing
Journal of Molecular Biology·2014· 53 citedOpen Access
Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease
Human Molecular Genetics·2014· 86 citedOpen Access
P1‐121: DETECTION OF DISTINCT PATHOLOGICAL TAU CONFORMATIONS IN CSF OF PATIENTS WITH NEURODEGENERATIVE DISEASES
Alzheimer s & Dementia·2014
Development of a fluorescent bar‐coding system for cell‐based proteomic libraries (912.13)
The FASEB Journal·2014
Conformational Features of Tau Fibrils from Alzheimer’s Disease Brain Are Faithfully Propagated by Unmodified Recombinant Protein
Biochemistry·2013· 86 citedOpen Access
Detection of pathological tau conformers in cerebrospinal fluid
The FASEB Journal·2013
Convergent Replication of Mouse Synthetic Prion Strains
American Journal Of Pathology·2013· 36 citedOpen Access
Protein Misfolding Detected Early in Pathogenesis of Transgenic Mouse Model of Huntington Disease Using Amyloid Seeding Assay
Journal of Biological Chemistry·2011· 32 citedOpen Access
De novo generation of prion strains
Nature Reviews Microbiology·2011· 90 citedOpen Access
A Disulfide-Free Single-Domain VL Intrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition
Journal of Molecular Biology·2011· 36 cited
Prions
Cold Spring Harbor Perspectives in Biology·2011· 459 citedOpen Access
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Frequent Co-authors

Stanley B. Prusiner(9), K. Dane Wittrup(6), Holger Wille(5), Olga A. Morozova(5), Giuseppe Legname(3), Stephen J. DeArmond(3), Fred E. Cohen(3), Vernon M. Ingram(3), Zachary M. March(3), Sharad Gupta(3), Yik A. Yeung(2), Jeffrey S. Swers(2), Christilyn Graff(2), Kurt Giles(2), Ilia V. Baskakov(2), Hilda Mirbaha(2), Dailu Chen(2), Olga A Morazova(2), Kiersten M. Ruff(2), Apurwa M Sharma(2)