Christilyn Graff

Medicine · Health Sciences

10h-index1.8kcitations14works16.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(10), Glycosylation and Glycoproteins Research(8), HER2/EGFR in Cancer Research(4), Growth Hormone and Insulin-like Growth Factors(2), Cell Adhesion Molecules Research(2)

Publications14 total

AIntibody: an experimentally validated in silico antibody discovery design challenge
Nature Biotechnology·2024· 16 citedOpen Access
Exposure Levels of Anti-LINGO-1 Li81 Antibody in the Central Nervous System and Dose-Efficacy Relationships in Rat Spinal Cord Remyelination Models after Systemic Administration
Journal of Pharmacology and Experimental Therapeutics·2011· 89 cited
A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
mAbs·2011· 78 citedOpen Access
Antibodies directed to α6β4 highlight the adhesive and signaling functions of the integrin in breast cancer cell lines
Cancer Biology & Therapy·2010· 6 citedOpen Access
Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis
Protein Science·2010· 101 citedOpen Access
Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties
Journal of Biological Chemistry·2009· 26 citedOpen Access
BIIB022, a fully human nonglycosylated γ4P antibody targeting IGF-1R for cancer therapy
2007· 7 cited
Rodent EAE model for the study of axon integrity and remyelination
Protocol Exchange·2007· 1 citedOpen Access
LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis
Nature Medicine·2007· 484 cited
Directed evolution of an anti-carcinoembryonic antigen scFv with a 4-day monovalent dissociation half-time at 37 C
Protein Engineering Design and Selection·2004· 139 citedOpen Access
Engineering Antibody Affinity by Yeast Surface Display
Methods in enzymology on CD-ROM/Methods in enzymology·2004· 137 cited
Theoretical analysis of antibody targeting of tumor spheroids: importance of dosage for penetration, and affinity for retention.
PubMed·2003· 209 cited
Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library
Nature Biotechnology·2003· 515 cited
Antibody engineering for tumor immunotherapy
DSpace@MIT (Massachusetts Institute of Technology)·2002· 2 citedOpen Access

Frequent Co-authors

Ellen A. Garber(5), K. Dane Wittrup(4), Sha Mi(4), Zhaohui Shao(3), Jianying Dong(3), Rachel Rennard(3), Stephen J. Demarest(3), Mitchell E. Reff(3), Kandasamy Hariharan(3), Scott Glaser(3), Yik A. Yeung(2), David W. Colby(2), Jeffrey S. Swers(2), Bing Hu(2), Kyungmin Hahm(2), Edward S. Hui(2), Qiuju Yuan(2), Wai Man Wong(2), Huanxing Su(2), Tak‐Ho Chu(2)