Zhaohui Shao

Biogen (United States) — United States

Neuroscience · Life Sciences

26h-index6.0kcitations36works0.02yr avg
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Research Topics

Neurogenesis and neuroplasticity mechanisms(13), Nerve injury and regeneration(12), Epigenetics and DNA Methylation(5), Genomics and Chromatin Dynamics(4), Cancer-related Molecular Pathways(4)

Publications36 total

Dynamic Proteome Changes in Cuprizone-Induced Demyelination and Remyelination in the Mouse Brain
Journal of Proteome Research·2025
Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546
ACS Medicinal Chemistry Letters·2021· 6 citedOpen Access
Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site
mAbs·2020· 21 citedOpen Access
LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway
Journal of Neuroscience·2017· 39 citedOpen Access
LINGO-1 Negatively Regulates Oligodendrocyte Differentiation by Blocking the β-integrin Signaling Pathway (I10.002)
Neurology·2016
LINGO-1 Negatively Regulates Oligodendrocyte Differentiation by Blocking the β-integrin Signaling Pathway (P5.298)
Neurology·2016
LINGO-1 regulates oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts
Molecular and Cellular Neuroscience·2014· 28 cited
Death receptor 6 (DR6) antagonist antibody is neuroprotective in the mouse SOD1G93A model of amyotrophic lateral sclerosis
Cell Death and Disease·2013· 41 citedOpen Access
A DR6/p75NTR complex is responsible for β-amyloid-induced cortical neuron death
Cell Death and Disease·2013· 54 citedOpen Access
Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination
Glia·2012· 57 cited
Exposure Levels of Anti-LINGO-1 Li81 Antibody in the Central Nervous System and Dose-Efficacy Relationships in Rat Spinal Cord Remyelination Models after Systemic Administration
Journal of Pharmacology and Experimental Therapeutics·2011· 89 cited
Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination
Nature Medicine·2011· 86 cited
Oligodendrocyte differentiation and myelination defects in OMgp null mice
Molecular and Cellular Neuroscience·2011· 22 cited
Production of a PEGylated Fab′ of the anti-LINGO-1 Li33 Antibody and Assessment of Its Biochemical and Functional Properties in Vitro and in a Rat Model of Remyelination
Bioconjugate Chemistry·2011· 26 cited
LINGO‐1 negatively regulates TrkB phosphorylation after ocular hypertension
European Journal of Neuroscience·2010· 33 cited
Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma
Neuroscience·2009· 72 citedOpen Access
Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells
Annals of Neurology·2009· 299 citedOpen Access
Combination Brain-Derived Neurotrophic Factor and LINGO-1 Fusion Protein Promote Long-Term Survival to Retinal Ganglion Cells after Ocular Hypertension
Neuroscience Research·2009
Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury
Molecular and Cellular Neuroscience·2008· 62 citedOpen Access
Rodent EAE model for the study of axon integrity and remyelination
Protocol Exchange·2007· 1 citedOpen Access
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Frequent Co-authors

Sha Mi(26), Xinhua Lee(18), R. Blake Pepinsky(11), Benxiu Ji(7), Blake Pepinsky(7), Kwok‐Fai So(6), Robert H. Miller(5), Vincent Jung(5), Paul D. Robbins(5), Melissa Levesque(4), John McCoy(4), Robert E. Kingston(4), Bing Hu(4), Ellen A. Garber(4), Wutian Wu(4), Guanrong Huang(4), Greg Thill(3), Jane K. Relton(3), Martin Scott(3), Christilyn Graff(3)