Blake Pepinsky

Biogen (United States) — United States

Neuroscience · Life Sciences

24h-index4.4kcitations45works1.72yr avg
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Research Topics

Neurogenesis and neuroplasticity mechanisms(9), Nerve injury and regeneration(8), Cell Adhesion Molecules Research(7), Parkinson's Disease Mechanisms and Treatments(4), Glycosylation and Glycoproteins Research(4)

Publications45 total

Balancing brain exposure, pharmacokinetics and safety of transferrin receptor antibodies for delivery of neuro-therapeutics
mAbs·2025Open Access
Comparative assessment of binding and functional differences of clinical antibodies targeting α-synuclein in cellular models of Parkinson’s disease
Biomedicine & Pharmacotherapy·2025Open Access
Quantification of cinpanemab (BIIB054) binding to α-synuclein in cerebrospinal fluid of phase 1 single ascending dose samples
Journal of Pharmacology and Experimental Therapeutics·2024· 5 cited
Tissue distribution of 35S-metabolically labeled neublastin (BG00010) in rats
Journal of Pharmaceutical and Biomedical Analysis·2020· 2 cited
Randomized phase I clinical trial of anti–α‐synuclein antibody BIIB054
Movement Disorders·2019· 187 citedOpen Access
A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble
Biochemistry·2017· 17 cited
LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway
Journal of Neuroscience·2017· 39 citedOpen Access
Engineering potent long-acting variants of the Wnt inhibitor DKK2
Protein Engineering Design and Selection·2017· 4 citedOpen Access
Investigating the Role of Artemin Glycosylation
Pharmaceutical Research·2016· 12 cited
Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve
Multiple Sclerosis Journal - Experimental Translational and Clinical·2016· 16 citedOpen Access
Artemin promotes functional long-distance axonal regeneration to the brainstem after dorsal root crush
Proceedings of the National Academy of Sciences·2015· 28 citedOpen Access
Inhibition of LINGO-1 promotes functional recovery after experimental spinal cord demyelination
Experimental Neurology·2015· 41 cited
A novel platform for engineering blood‐brain barrier‐crossing bispecific biologics
The FASEB Journal·2014· 145 citedOpen Access
LINGO-1 regulates oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts
Molecular and Cellular Neuroscience·2014· 28 cited
Meteorin reverses hypersensitivity in rat models of neuropathic pain
Experimental Neurology·2012· 23 cited
Oligodendrocyte differentiation and myelination defects in OMgp null mice
Molecular and Cellular Neuroscience·2011· 22 cited
Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells
Annals of Neurology·2009· 299 citedOpen Access
Rodent EAE model for the study of axon integrity and remyelination
Protocol Exchange·2007· 1 citedOpen Access
LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis
Nature Medicine·2007· 484 cited
Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models
Proceedings of the National Academy of Sciences·2007· 162 citedOpen Access
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Frequent Co-authors

Sha Mi(9), Kwok‐Fai So(7), Zhaohui Shao(7), Xinhua Lee(5), James Barsoum(4), Bing Hu(4), Roy R. Lobb(4), Sylvia A. Rabacchi(4), Dinah W.Y. Sah(4), Stephen E. Fawell(3), Yasmin Daikh(3), Ellen A. Garber(3), Vincent Jung(3), Christopher D. Benjamin(3), Lee Walus(3), Dane Worley(3), Diane R. Leone(3), Yuting Liu(3), Andreas Weihofen(3), Richard L. Cate(3)