Kathy Hsiao

Foundation for Biomedical Research — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index4.4kcitations19works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Hedgehog Signaling Pathway Studies(4), Epigenetics and DNA Methylation(3), Protein Tyrosine Phosphatases(3), Hepatitis C virus research(2), RNA and protein synthesis mechanisms(2)

Publications19 total

Abstract 1176: Preclinical characterization of the pharmacokinetic-pharmacodynamics-efficacy relationship of novel allosteric SHP2 inhibitors
Cancer Research·2017
Abstract 2084: Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers
Cancer Research·2017
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
Nature·2016· 894 cited
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway
Nature Medicine·2010· 252 citedOpen Access
Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
Science Translational Medicine·2010· 553 cited
Abstract 4290: The smoothened antagonist NVP-LDE225 targets stroma and cancer stem cells in primary human pancreatic tumor xenografts
Cancer Research·2010· 4 cited
Abstract 1976: The discovery of mechanisms of resistance to SMO antagonists and the therapeutic implications
Cancer Research·2010
The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins
Journal of Virology·1997· 107 citedOpen Access
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
Chemistry & Biology·1997· 275 citedOpen Access
Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells
Journal of Virology·1997· 84 citedOpen Access
Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme
Science·1997· 1.1k cited
Superinduction of mouse epidermal ornithine decarboxylase activity by repeated 12-0-tetradecanoylphorbol-13-acetate treatments
Molecular and Cellular Biochemistry·1996· 11 cited
X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
Cell·1995· 835 citedOpen Access
Three distinct messenger RNAs can encode the human immunosuppressant-binding protein FKBP12
Gene·1994· 9 cited
Spin Filter Perfusion System for High Density Cell Culture: Production of Recombinant Urinary Type Plasminogen Activator in CHO Cells
Nature Biotechnology·1990· 110 cited
150 Biological characterization of fully glycosylated recombinant SCU-PA
Fibrinolysis and Proteolysis·1988· 1 cited
Identification of more than 500 RFLPs by screening random genomic clones.
PubMed·1988· 64 cited
Cloning of eukaryotic genes in single-strand phage vectors: the human interferon genes
Gene·1984· 16 cited
Calcium uptake mechanisms affected by some convulsant and anticonvulsant drugs
Brain Research·1981· 43 cited

Frequent Co-authors

Markus Warmuth(6), William R. Sellers(6), Jing Yuan(5), Michael Su(4), Silvia Buonamici(4), Joseph F. Kelleher(4), Marion Dorsch(4), Ying-Nan P. Chen(3), Matthew J. LaMarche(3), Brant Firestone(3), Laura R. La Bonte(3), Shumei Liu(3), Matthew J. Meyer(3), Minying Pu(3), Pascal D. Fortin(3), Juliet Williams(3), Anthony Vattay(3), Lance Ostrom(3), John E. Monahan(3), Stefan Peukert(3)