H. Brognaro

Computer Science · Physical Sciences

11h-index759citations66works3.72yr avg
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Research Topics

Computational Drug Discovery Methods(23), SARS-CoV-2 and COVID-19 Research(19), Enzyme Structure and Function(12), Enzyme Production and Characterization(7), interferon and immune responses(7)

Publications66 total

Crystal structure of Isoform Chitin Binding Protein from Iberis umbellata L.
2025
Growing a single suspended perfect protein crystal in a fully noncontact manner
International Journal of Biological Macromolecules·2024· 3 cited
SARS-CoV-2 Mpro responds to oxidation by forming disulfide and NOS/SONOS bonds
Nature Communications·2024· 8 citedOpen Access
Initiation and modulation of Tau protein phase separation by the drug suramin
Scientific Reports·2023· 27 citedOpen Access
Formation kinetics and physicochemical properties of mesoscopic Alpha-Synuclein assemblies modulated by sodium chloride and a distinct pulsed electric field
Soft Matter·2023· 3 citedOpen Access
Structure and Dynamics of the Penicillin-Binding Protein 3 from Staphylococcus Epidermidis Native and in Complex with Cefotaxime and Vaborbactam
International Journal of Applied Biology and Pharmaceutical Technology·2023Open Access
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease
Communications Biology·2022· 55 citedOpen Access
Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease
Frontiers in Chemistry·2022· 22 citedOpen Access
Exploring Nucleation Pathways in Distinct Physicochemical Environments Unveiling Novel Options to Modulate and Optimize Protein Crystallization
Crystals·2022· 5 citedOpen Access
Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates
The EMBO Journal·2022· 86 citedOpen Access
Structure and activity of the DHNA Coenzyme-A Thioesterase from Staphylococcus aureus providing insights for innovative drug development
Scientific Reports·2022· 2 citedOpen Access
Understanding coalescence of phase separated droplets and verification via growing a single suspended crystal
2022Open Access
Biomolecular Tau condensation is linked to Tau accumulation at the nuclear envelope
2022· 4 citedOpen Access
SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design
2021· 3 citedOpen Access
Structure and Activity of the DHNA Coenzyme-A Thioesterase from Staphylococcus aureus Providing Insights for Innovative Drug Development
Research Square (Research Square)·2021Open Access
Genome and Secretome Analysis of Staphylotrichum longicolleum DSM105789 Cultured on Agro-Residual and Chitinous Biomass
Microorganisms·2021· 6 citedOpen Access
Structure of SARS-CoV-2 Papain-like protease PLpro in complex with 4-(2-hydroxyethyl)phenol
2021
Structure of SARS-CoV-2 Papain-like protease PLpro in complex with p-hydroxybenzaldehyde
2021
Structure of SARS-CoV-2 Papain-like protease PLpro in complex with 3, 4-Dihydroxybenzoic acid, methyl ester
2021
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
Science·2021· 354 citedOpen Access
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Frequent Co-authors

Sven Falke(36), Christian Betzel(27), P. Reinke(23), J. Lieske(23), Thomas J. Lane(22), F. Koua(22), Oleksandr Yefanov(22), Luca Gelisio(22), M. Galchenkova(22), B. Alves Franca(22), Henry N. Chapman(22), Helen M. Ginn(21), S. Saouane(21), M. Groessler(21), F. Trost(21), N. Werner(21), M. Schwinzer(21), Bernhard Ellinger(21), Alke Meents(21), A. Tolstikova(20)