Hugo J.G. Snippert

Utrecht University — Netherlands

Medicine · Health Sciences

45h-index24.5kcitations128works4.42yr avg
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Research Topics

Cancer Cells and Metastasis(40), Cancer Genomics and Diagnostics(25), Colorectal Cancer Treatments and Studies(21), Melanoma and MAPK Pathways(19), Hippo pathway signaling and YAP/TAZ(17)

Publications128 total

Analysis of experimental colorectal liver metastases identifies distinct proliferation-independent transcriptional programs in micro- versus macrometastases
Journal of Translational Medicine·2025Open Access
Impact of treatment history on drug resistance of metastatic colorectal cancer organoids
iScience·2025Open Access
Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state
Cell Reports·2025· 2 citedOpen Access
APOBEC3A drives deaminase mutagenesis in human gastric epithelium
Genome Research·2025· 1 citedOpen Access
Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients
Nature Communications·2025· 2 citedOpen Access
Stem cells actively suppress regenerative plasticity in human colon
2025Open Access
BRAFV600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer
iScience·2025Open Access
Resistance to MAPK Pathway Inhibition in BRAF-V600E Mutant Colorectal Cancer Can Be Overcome with Insulin Receptor/Insulin-like Growth Factor-1 Receptor Inhibitors
Organoids·2025Open Access
BRAFV600E augments WNT signaling in colorectal cancer via aberrant DNA methylation
iScience·2025Open Access
Table S4 from Response to Systemic Therapies in Patient-Derived Cell Lines from Primary and Recurrent Adult Granulosa Cell Tumors
2025Open Access
Data from Response to Systemic Therapies in Patient-Derived Cell Lines from Primary and Recurrent Adult Granulosa Cell Tumors
2025Open Access
Table S3 from Response to Systemic Therapies in Patient-Derived Cell Lines from Primary and Recurrent Adult Granulosa Cell Tumors
2025Open Access
Methods S1 from Response to Systemic Therapies in Patient-Derived Cell Lines from Primary and Recurrent Adult Granulosa Cell Tumors
2025Open Access
Figure S2 from Response to Systemic Therapies in Patient-Derived Cell Lines from Primary and Recurrent Adult Granulosa Cell Tumors
2025Open Access
Table S1 from Response to Systemic Therapies in Patient-Derived Cell Lines from Primary and Recurrent Adult Granulosa Cell Tumors
2025Open Access
Table S2 from Response to Systemic Therapies in Patient-Derived Cell Lines from Primary and Recurrent Adult Granulosa Cell Tumors
2025Open Access
Table S5 from Response to Systemic Therapies in Patient-Derived Cell Lines from Primary and Recurrent Adult Granulosa Cell Tumors
2025Open Access
Figure S1 from Response to Systemic Therapies in Patient-Derived Cell Lines from Primary and Recurrent Adult Granulosa Cell Tumors
2025Open Access
Abstract B003: BRAFV600E is essential for maintenance of the CpG island methylator phenotype and DNA methylation of PRC2 target genes in colon cancer
Cancer Research·2025
Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia
2024· 2 citedOpen Access
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Frequent Co-authors

Hans Clevers(30), Johan H. van Es(11), Harry Begthel(10), Bas Ponsioen(10), Nick Barker(9), Jacco van Rheenen(9), Koen C. Oost(9), Marc van de Wetering(6), Daniel E. Stange(6), Peter J. Peters(6), Maaike van den Born(6), Ingrid Verlaan-Klink(6), Maria C. Heinz(5), Toshiro Sato(4), Benjamin D. Simons(4), Jeroen Korving(4), Geert J.P.L. Kops(4), Maria Kasper(4), Johannes L. Bos(4), Saskia I. J. Ellenbroek(4)