Edwin Pozharski

University of Maryland, Baltimore — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index3.8kcitations147works1.82yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(21), Enzyme Structure and Function(19), Protein Structure and Dynamics(14), RNA Interference and Gene Delivery(12), Clostridium difficile and Clostridium perfringens research(12)

Publications147 total

Cryo‐EM Structures Reveal the Molecular Basis of Asymmetric Allosteric Activation by MMOB in the Hydroxylase of Soluble Methane Monooxygenase
Advanced Science·2026Open Access
Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk
Nature Communications·2025· 3 citedOpen Access
Pore formation by the CDTb component of the Clostridioides difficile binary toxin is Ca2+-dependent
Communications Biology·2025· 2 citedOpen Access
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV
Structure·2025· 2 citedOpen Access
Heartbeat-like dynamics drives oxygen activation in methane monooxygenase
2025Open Access
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV
Digital Repository at the University of Maryland (University of Maryland College Park)·2025Open Access
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV
2024· 1 citedOpen Access
Structural and Functional Insights into the Delivery Systems of Bacillus and Clostridial Binary Toxins
Toxins·2024Open Access
Directly visualizing individual polyorganophosphazenes and their single-chain complexes with proteins
Communications Materials·2024· 8 citedOpen Access
Cryo-EM and AFM visualize linear polyorganophosphazene: individual chains and single-chain assemblies with proteins
Research Square (Research Square)·2023Open Access
Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir
Nature Communications·2023· 10 citedOpen Access
Dendritic Cell‐Mediated Cross‐Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS‐CoV‐2
Advanced Science·2023· 3 citedOpen Access
Membrane binding and pore formation is Ca <sup>2+</sup> -dependent for the <i>Clostridioides difficile</i> binary toxin
2023Open Access
Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies
Nature Communications·2023· 31 citedOpen Access
Clostridium difficile binary toxin translocase CDTb tetradecamer in symmetric and asymmetric conformations
EMPIAR dataset·2023Open Access
Structure-function Analyses Reveal Key Molecular Determinants of HIV-1 CRF01_AE Resistance to the Entry Inhibitor Temsavir
2023· 3 citedOpen Access
Characterizing inhibitors of human AP endonuclease 1
PLoS ONE·2023· 16 citedOpen Access
A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
Cell Reports·2022· 128 citedOpen Access
Physiologically Relevant Free Ca2+ Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6
Journal of Molecular Biology·2021· 10 citedOpen Access
An anti-SARS-CoV-2 non-neutralizing antibody with Fc-effector function defines a new NTD epitope and delays neuroinvasion and death in K18-hACE2 mice
2021· 14 citedOpen Access
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Frequent Co-authors

Robert C. MacDonald(9), Alexander C. Drohat(9), Franz J. St John(8), Kristen M. Varney(8), Eric A. Toth(7), L.S. Pidugu(6), Alexander D. MacKerell(6), David J. Weber(5), Mark A. Wilson(4), Jason C. Hurlbert(4), Paul T. Wilder(4), Gregory A. Petsko(3), Vera A. Rakhmanova(3), Javier González(3), Christian X. Weichenberger(3), Bernhard Rupp(3), Christopher T. Coey(3), Shuja Shafi Malik(3), Thomas H. Charpentier(3), Melissa A. Liriano(3)