Laetitia Francelle

Northwestern University — United States

Neuroscience · Life Sciences

14h-index1.0kcitations23works0.02yr avg
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Research Topics

Genetic Neurodegenerative Diseases(13), Mitochondrial Function and Pathology(8), Neurological disorders and treatments(6), Parkinson's Disease Mechanisms and Treatments(4), Epigenetics and DNA Methylation(2)

Publications23 total

CLN7/MFSD8 may be an important factor for SARS-CoV-2 cell entry
iScience·2022· 2 citedOpen Access
Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking
Neuron·2021· 110 citedOpen Access
Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity
Scientific Reports·2020· 55 citedOpen Access
The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin
Brain·2018· 43 citedOpen Access
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
PLoS Biology·2017· 19 citedOpen Access
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
PLoS Biology·2017· 212 citedOpen Access
Contribution of Neuroepigenetics to Huntington’s Disease
Frontiers in Human Neuroscience·2017· 59 citedOpen Access
Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats
Hippocampus·2017· 33 citedOpen Access
B40 In vivo imaging of brain glutamate defects in a knock-in mouse model of huntington’s disease
Journal of Neurology Neurosurgery & Psychiatry·2016· 1 cited
In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease
NeuroImage·2016· 81 citedOpen Access
Characterization of the striatal kinase Dclk3 and its neuroprotective effects againstmutant huntingtin
HAL (Le Centre pour la Communication Scientifique Directe)·2015
The striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo
Neurobiology of Aging·2014· 52 citedOpen Access
A Study of Striatal Markers as Disease Modifiers in Huntington's Disease
HAL (Le Centre pour la Communication Scientifique Directe)·2014· 1 citedOpen Access
Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease
Human Molecular Genetics·2014· 31 citedOpen Access
Biological Features of Herpes Simplex Virus Type 1 Latency in Mice According to Experimental Conditions and Type of Neurones
Investigative Ophthalmology & Visual Science·2014· 5 cited
Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease
Frontiers in Cellular Neuroscience·2014· 39 citedOpen Access
Mutant huntingtin alters Tau phosphorylation and subcellular distribution
Human Molecular Genetics·2014· 85 citedOpen Access
more vulnerable to mutant huntingtin in Huntington's disease
2014
The newly identified striatal marker Doublecortin-like kinase 3 (Dclk3) may be amolecular determinant of striatal vulnerability in Huntington’s disease
HAL (Le Centre pour la Communication Scientifique Directe)·2013
High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes
Stem Cells·2013· 81 cited
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Frequent Co-authors

Emmanuel Brouillet(13), Laurie Galvan(8), Martine Guillermier(7), Marie‐Claude Gaillard(7), Fanny Petit(7), Noëlle Dufour(7), Nicole Déglon(7), Tiago F. Outeiro(6), Gilles Bonvento(6), Jean‐Marc Elalouf(5), Michel de Chaldée(5), María-Angeles Carrillo-de Sauvage(4), Lucie de Longprez(4), Philippe Hantraye(4), Diane Houitte(4), Ellen Gerhardt(3), Karine Cambon(3), Julien Valette(3), Julien Flament(3), Karine Mérienne(3)