Frederike A. Hartl

University of Freiburg — Germany

Immunology and Microbiology · Life Sciences

10h-index840citations15works3.52yr avg
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Research Topics

Immune Cell Function and Interaction(10), T-cell and B-cell Immunology(8), CAR-T cell therapy research(5), Immunodeficiency and Autoimmune Disorders(2), Galectins and Cancer Biology(2)

Publications15 total

Controlling TCR and CAR activation by targeting LCK recruitment with a first-in-class small-molecule inhibitor
2025· 1 citedOpen Access
Phospho-mimetic CD3ε variants prevent TCR and CAR signaling
Frontiers in Immunology·2024· 6 citedOpen Access
Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK
Journal of Clinical Immunology·2023· 7 citedOpen Access
A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation
The Journal of Experimental Medicine·2023· 16 citedOpen Access
Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling
Cells·2021· 23 citedOpen Access
Author Correction: Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function
Nature Immunology·2020· 2 cited
Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function
Nature Immunology·2020· 115 cited
Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor
Frontiers in Immunology·2018· 24 citedOpen Access
Oncogenic JAK2 <sup>V617F</sup> causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms
Science Translational Medicine·2018· 219 citedOpen Access
Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance
Nature Immunology·2017· 57 citedOpen Access
Correction: Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning
The Journal of Immunology·2016· 3 cited
A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation
Immunity·2016· 230 citedOpen Access
Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells
Blood·2016· 51 citedOpen Access
Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning
The Journal of Immunology·2015· 27 cited
The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing
Cell Reports·2014· 59 citedOpen Access

Frequent Co-authors

Susana Minguet(15), Wolfgang W. Schamel(11), Esmeralda Beck-Garcìa(6), O. Sascha Yousefi(6), Anna Morath(4), Elaine P. Dopfer(4), Robert Zeiser(4), Nadine M. Woessner(4), Gina J. Fiala(4), Piyamaporn Wipa(4), Sutatip Pongcharoen(4), Simon M. Brandl(3), Pankaj Mishra(3), Maja Köhn(3), Stefan Günther(3), Pussadee Paensuwan(3), Jatuporn Ngoenkam(3), Balbino Alarcón(2), Alessandro Prestipino(2), Wolfgang Melchinger(2)