Nigel J. Waterhouse

AstraZeneca (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

44h-index9.3kcitations100works0.52yr avg
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Research Topics

Cell death mechanisms and regulation(45), Mitochondrial Function and Pathology(18), Autophagy in Disease and Therapy(16), Immune Cell Function and Interaction(16), Immunotherapy and Immune Responses(13)

Publications100 total

Two-Year Inhalation Studies in Mice and Rats With HFO-1234ze(E), a Near Zero Global Warming Potential Propellant for Use in Pressurized Metered Dose Inhalers
International Journal of Toxicology·2025Open Access
Strategies to reduce the use of non-human primates in development of oncology ADCs with cytotoxic payloads
Regulatory Toxicology and Pharmacology·2025· 1 cited
Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors
Journal for ImmunoTherapy of Cancer·2023· 33 citedOpen Access
341 A phase Ib expansion cohort of pixatimod plus nivolumab in previously treated, microsatellite stable metastatic colorectal cancer (MSS mCRC)
Regular and Young Investigator Award Abstracts·2021Open Access
Immune contexture analysis in immuno‐oncology: applications and challenges of multiplex fluorescent immunohistochemistry
Clinical & Translational Immunology·2020· 42 citedOpen Access
WITHDRAWN
Experimental Hematology·2019Open Access
HUMAN PERIPHERAL BLOOD DNAM-1NEG NK CELLS ARE A TERMINALLY DIFFERENTIATED SUBSET WITH IMMUNOREGULATORY PROPERTIES
Experimental Hematology·2019Open Access
Human peripheral blood DNAM-1neg NK cells are a terminally differentiated subset with limited effector functions
Blood Advances·2019· 26 citedOpen Access
FGFR inhibition in endometrial cancer induces caspase-independent cell death that can be augmented with ABT-737
Molecular Cancer Therapeutics·2018
Abstract LB-B31: FGFR inhibition in endometrial cancer induces caspase-independent cell death that can be augmented with ABT-737
Molecular Cancer Therapeutics·2018
Human papillomavirus E7 oncoprotein expression by keratinocytes alters the cytotoxic mechanisms used by CD8 T cells
Oncotarget·2017· 10 citedOpen Access
Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells
Oncogene·2017· 83 cited
Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity
Cell Death and Disease·2017· 483 citedOpen Access
Analysis of Cytochrome <i>c</i> Release by Immunocytochemistry
Cold Spring Harbor Protocols·2016· 14 cited
Dead Cert: Measuring Cell Death
Cold Spring Harbor Protocols·2016· 76 citedOpen Access
Measuring Mitochondrial Transmembrane Potential by TMRE Staining
Cold Spring Harbor Protocols·2016· 196 cited
Quantitation of Apoptosis and Necrosis by Annexin V Binding, Propidium Iodide Uptake, and Flow Cytometry
Cold Spring Harbor Protocols·2016· 518 cited
Detecting Cleaved Caspase-3 in Apoptotic Cells by Flow Cytometry
Cold Spring Harbor Protocols·2016· 231 cited
Detection of DNA Fragmentation in Apoptotic Cells by TUNEL
Cold Spring Harbor Protocols·2016· 93 cited
Measuring the DNA Content of Cells in Apoptosis and at Different Cell-Cycle Stages by Propidium Iodide Staining and Flow Cytometry
Cold Spring Harbor Protocols·2016· 79 cited
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Frequent Co-authors

Douglas R. Green(15), Joseph A. Trapani(12), Lisa C. Crowley(10), Karin Sedelies(8), Melinda E. Christensen(8), Joshua C. Goldstein(6), Brooke J. Marfell(6), Phillip I. Bird(5), Donald D. Newmeyer(4), Jane Oliaro(4), Mark J. Smyth(4), Ricky W. Johnstone(4), Kylie A. Browne(4), Vivien R. Sutton(4), Adrian P. Scott(3), Jean‐Ehrland Ricci(3), Martin Schüler(3), Grace Chojnowski(3), Mandy Ludford‐Menting(3), Anupama Pasam(3)