James J. Champoux

University of Washington — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

53h-index12.4kcitations132works0.02yr avg
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Research Topics

Cancer therapeutics and mechanisms(72), DNA and Nucleic Acid Chemistry(38), HIV Research and Treatment(31), HIV/AIDS drug development and treatment(28), Bioactive Compounds and Antitumor Agents(24)

Publications132 total

DNA Recognition/Processing | DNA Topoisomerases: Type I
Elsevier eBooks·2013
DNA Topoisomerases: Type I
Encyclopedia of Biological Chemistry·2013· 2 cited
Human DNA Topoisomerase I: Structure, Enzymology and Biology
Cancer drug discovery and develogment/Cancer drug discovery and development·2011· 2 cited
Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1
Biochemical Journal·2011· 53 citedOpen Access
Multiple Nucleotide Preferences Determine Cleavage-Site Recognition by the HIV-1 and M-MuLV RNases H
Journal of Molecular Biology·2010· 11 citedOpen Access
Preferred Sequences within a Defined Cleavage Window Specify DNA 3′ End-directed Cleavages by Retroviral RNases H
Journal of Biological Chemistry·2009· 13 citedOpen Access
Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA
FEBS Journal·2009· 17 citedOpen Access
Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription
FEBS Journal·2009· 74 citedOpen Access
Assays for the Preferential Binding of Human Topoisomerase I to Supercoiled DNA
Methods in molecular biology·2009· 8 citedOpen Access
Arylstibonic acids: Novel inhibitors and activators of human topoisomerase IB
Bioorganic Chemistry·2008· 13 citedOpen Access
RNase H activity: Structure, specificity, and function in reverse transcription
Virus Research·2008· 145 citedOpen Access
Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?
The EMBO Journal·2007· 140 citedOpen Access
Substitution of alanine for tyrosine-64 in the fingers subdomain of M-MuLV reverse transcriptase impairs strand displacement synthesis and blocks viral replication in vivo
Virology·2007· 11 citedOpen Access
Pausing during Reverse Transcription Increases the Rate of Retroviral Recombination
Journal of Virology·2006· 33 citedOpen Access
The Structure of the Transition State of the Heterodimeric Topoisomerase I of Leishmania donovani as a Vanadate Complex with Nicked DNA
Journal of Molecular Biology·2006· 79 cited
Sequence, Distance, and Accessibility Are Determinants of 5′-End-directed Cleavages by Retroviral RNases H
Journal of Biological Chemistry·2005· 35 citedOpen Access
Human Tdp1 Cleaves a Broad Spectrum of Substrates, Including Phosphoamide Linkages
Journal of Biological Chemistry·2005· 217 citedOpen Access
SCAN1 mutant Tdp1 accumulates the enzyme–DNA intermediate and causes camptothecin hypersensitivity
The EMBO Journal·2005· 196 citedOpen Access
Human DNA topoisomerase I: relaxation, roles, and damage control
Chromosoma·2005· 226 cited
Requirements for DNA Unpairing during Displacement Synthesis by HIV-1 Reverse Transcriptase
Journal of Biological Chemistry·2004· 9 citedOpen Access
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Frequent Co-authors

Lance Stewart(10), Wim G. J. Hol(9), Heidrun Interthal(8), Matthew R. Redinbo(5), Knut Madden(4), Gregory C. Ireton(4), D.R. Davies(4), Michael D. Been(3), Alison J. Rattray(3), John B. Leppard(2), Hong Jing Chen(2), Sharon J. Schultz(2), Betty L. McConaughy(2), Katherine Pullen(2), Peter Kühn(1), Xiayang Qiu(1), Alejandro Merino(1), William S. Lane(1), Danny Reinberg(1), Renato Dulbecco(1)