Chung K. Chu

University of Georgia — United States

Medicine · Health Sciences

47h-index7.6kcitations266works3.52yr avg
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Research Topics

HIV/AIDS drug development and treatment(171), Biochemical and Molecular Research(80), HIV Research and Treatment(79), Carbohydrate Chemistry and Synthesis(46), Synthesis and Characterization of Heterocyclic Compounds(36)

Publications266 total

Synthesis and Antiviral Evaluation of Unexplored Dioxolane-Derived 7-Deazapurine Nucleoside Analogues against Epstein–Barr Virus (EBV)
ACS Medicinal Chemistry Letters·2025· 1 citedOpen Access
Chemical Space of Fluorinated Nucleosides/Nucleotides in Biomedical Research and Anticancer Drug Discovery
Chemistry·2025· 4 citedOpen Access
Enantioselective Synthesis of β-<scp>l</scp>-5-[(<i>E</i>)-2-Bromovinyl)-1-((2<i>S</i>,4<i>S</i>)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl) Uracil)] (<scp>l</scp>-BHDU) <i>via</i> Chiral Pure <scp>l</scp>-Dioxolane
The Journal of Organic Chemistry·2024· 1 citedOpen Access
Synthesis of Fluorinated Nucleosides/Nucleotides and Their Antiviral Properties
Molecules·2024· 8 citedOpen Access
CCDC 2237809: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
A Stereoselective Synthesis of 4′‐ <i>α</i> ‐Fluoro‐methyl Carbocyclic Nucleoside Analogs
ChemistrySelect·2023· 2 citedOpen Access
Prodrug Strategies for the Development of β-<scp>l</scp>-5-((<i>E</i>)-2-Bromovinyl)-1-((2<i>S</i>,4<i>S</i>)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (<scp>l</scp>-BHDU) against Varicella Zoster Virus (VZV)
Journal of Medicinal Chemistry·2023· 6 citedOpen Access
Synthesis of 2′-deoxy-2′-fluoro-2′-C-methyl spiro cyclopentyl carbocyclic uridine analog as potential inhibitors of HCV NS5B polymerase
Nucleosides Nucleotides & Nucleic Acids·2020· 10 cited
β-L-1-[5-(E-2-Bromovinyl)-2-(Hydroxymethyl)-1,3-Dioxolan-4-yl)] Uracil (L-BHDU) Inhibits Varicella Zoster Virus Replication by Depleting the Cellular dTTP Pool
2020· 2 citedOpen Access
EXPLORING THE HETEROGENEITY OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A LATENT CLASS ANALYSIS
Respirology·2019Open Access
ASSESSING INHALER USE TECHNIQUE IN COPD PATIENTS
Respirology·2019· 1 citedOpen Access
Synthesis of an Anti-hepatitis B Agent, 2′-Fluoro-6′-methylene-carbocyclic Adenosine (FMCA) and Its Phosphoramidate (FMCAP)
The Journal of Organic Chemistry·2018· 13 cited
2′‐Fluoro‐6′‐methylene carbocyclic adenosine and its phosphoramidate prodrug: A novel anti‐HBV agent, active against drug‐resistant HBV mutants
Medicinal Research Reviews·2018· 16 cited
β-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism
Antiviral Research·2014· 16 citedOpen Access
Stereoselective Synthesis of 2′-Fluoro-6′-methylene Carbocyclic Adenosine via Vince Lactam
The Journal of Organic Chemistry·2014· 16 cited
Pharmacological Reversal of Histone Methylation Presensitizes Pancreatic Cancer Cells to Nucleoside Drugs: In Vitro Optimization and Novel Nanoparticle Delivery Studies
PLoS ONE·2013· 25 citedOpen Access
Abstract 1025: Optimized DZNep exposure presensitizes pancreatic cancer cells to anticancer nucleoside analogues: potential clinical implications.
Cancer Research·2013
2′-Fluoro-6′-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudine–entecavir resistant triple mutant and its mechanism of action
Bioorganic & Medicinal Chemistry Letters·2012· 16 cited
Corrigendum to “Antiviral activity of novel 2′-fluoro-6′-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants” [Bioorg. Med. Chem. Lett. 21 (2011) 6328–6331]
Bioorganic & Medicinal Chemistry Letters·2012
ChemInform Abstract: Antiviral Activity of Novel 2′‐Fluoro‐6′‐methylene‐carbocyclic Adenosine Against Wild‐Type and Drug‐Resistant Hepatitis B Virus Mutants.
ChemInform·2012
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Frequent Co-authors

Raymond F. Schinazi(20), Joseph Warren Beach(9), Yung‐Chi Cheng(9), Lak Shin Jeong(8), Antônio J. Alves(5), Lieven Stuyver(4), Phillip M. Tharnish(4), Michaël Otto(4), Hea O. Kim(4), Yongseok Choi(4), Soon Kil Ahn(4), Giuseppe Gumina(4), Tamara R. McBrayer(3), Janga Ramesh Babu(3), Robert W. Sidwell(3), Youhoon Chong(3), Hyunah Choo(3), Patrick Van Roey(3), G. V. ULLAS(3), Shwu-Huey Liu(3)