Lak Shin Jeong

Inje University — South Korea

Medicine · Health Sciences

49h-index8.7kcitations480works1.72yr avg
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Research Topics

HIV/AIDS drug development and treatment(148), Biochemical and Molecular Research(100), Adenosine and Purinergic Signaling(97), Carbohydrate Chemistry and Synthesis(66), Synthesis and Characterization of Heterocyclic Compounds(57)

Publications480 total

Discovery of a Novel Template, <i>N</i> 3-1′-Homologated 4′-Truncated Thiosugar-Substituted Xanthine as an A <sub>3</sub> AR Antagonist via Conversion of an A <sub>1</sub> AR Antagonist
ACS Medicinal Chemistry Letters·2025Open Access
Structure-activity relationship analysis of 5′-substituted C2-hexynyl-4′-thioadenosine analogs as dual A2A/A3 adenosine receptor agonists with tunable selectivity and anti-inflammatory activity
European Journal of Medicinal Chemistry·2025
Design, Synthesis, and Biological Evaluation of 5′,7-Disubstituted 7-Deaza-adenosine Analogues as Irreversible Pan-FGFR Inhibitors
Pharmaceuticals·2025Open Access
Design, Synthesis, and Biological Evaluation of C2-(N-Substituted Amino) Truncated 4′-Thioadenosine Derivatives as A <sub>2A</sub> AR and A <sub>3</sub> AR Dual Ligands
ACS Medicinal Chemistry Letters·2025Open Access
Comparative analysis of LJ-4378 and tirzepatide in mouse models of obesity and weight regain
Archives of Pharmacal Research·2025Open Access
Late‐Stage Conversion of Terminal Alkynes to Nitriles in Nucleoside Scaffolds: A Tool for Diversification
Asian Journal of Organic Chemistry·2025Open Access
Design and development of 5′-modified 7-substituted 4′-thionucleosides as potent Haspin inhibitors: Synthesis and biological evaluation
Bioorganic Chemistry·2025
Design, Synthesis, and Antiviral Activity of 8-Aza Fluoroneplanocin Derivatives Targeting SAH Hydrolase and Viral RdRp
ACS Medicinal Chemistry Letters·2025
Regio- and Stereoselective Ribose Modification in Truncated 2,8-Disubstituted Adenosine Scaffold to Develop Highly Potent A<sub>2A</sub> Adenosine Receptor Antagonists
Journal of Medicinal Chemistry·2025· 1 cited
Identification of 4′-Thiouridine as an Orally Available Antiviral Agent Targeting Both RdRp and NiRAN Functions of SARS-CoV-2 Nsp12
Journal of Medicinal Chemistry·2025· 3 cited
Targeting HASPIN in gemcitabine-resistant pancreatic cancer cells by lead optimization of thioadenosine analogue
Biomedicine & Pharmacotherapy·2025· 2 citedOpen Access
Biological activity and therapeutic potential of SAFA-based long-acting rhTSH
Endocrine Abstracts·2025
Design, Synthesis and Biological Evaluation of <i>N</i>6‐Substituted‐<i>C</i>2‐Alkynyl‐4′‐Thionucleoside and 4′‐Trucatedthionucleoside Derivatives as Novel A<sub>3</sub> Adenosine Receptor Ligands
ChemMedChem·2025· 1 citedOpen Access
Structure–Activity Relationship Analysis of 2-Aryl-8-alkynyl Adenine and Nucleoside Scaffolds as A<sub>3</sub> Adenosine Receptor Ligands
ACS Medicinal Chemistry Letters·2025· 1 cited
Steric influence of 4′-position substituents and C2-Hexynyl group on A3AR antagonism in truncated 4′-Thioadenosine derivatives
Bioorganic Chemistry·2025· 1 cited
Trifluoromethylation on a Nucleoside Sugar Scaffold: Design and Synthesis of 6′-Trifluoromethylcyclopentenyl-purine and -pyrimidine Nucleosides
Organic Letters·2025· 1 cited
Design, synthesis, and biological evaluation of 5ʹ-deoxy (N)-methanocarbanucleoside derivatives as A3 adenosine receptor ligands
Bioorganic & Medicinal Chemistry Letters·2025· 1 cited
1,550-nm photonic crystal surface-emitting laser diode fabricated by single deep air-hole etch
Nanophotonics·2025· 3 citedOpen Access
Design, synthesis, and biological evaluation of 5',7-disubstituted 7-deaza-adenosine analogues as irreversible pan-FGFR inhibitors
SSRN Electronic Journal·2025Open Access
A3AR antagonism mitigates metabolic dysfunction-associated steatotic liver disease by exploiting monocyte-derived Kupffer cell necroptosis and inflammation resolution
Metabolism·2024· 6 cited
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Frequent Co-authors

Hea Ok Kim(14), Joseph Warren Beach(13), Hyung Ryong Moon(11), Raymond F. Schinazi(10), Hyuk Woo Lee(10), Sang Kook Lee(9), Chung K. Chu(8), Jinha Yu(8), Won Jun Choi(8), Lijun Jia(7), Antônio J. Alves(7), Kenneth A. Jacobson(6), Moon Woo Chun(6), Robert M. Hoffman(5), Satyanarayana Nampalli(5), Yongfu Pan(4), Yiwei Chu(4), Hea O. Kim(4), Hui Qi(4), Kirupathevy Shanmuganathan(4)