Fred K. Friedman

Cancer Institute (WIA) — India

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

28h-index2.8kcitations137works0.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(49), Cancer-related Molecular Pathways(23), Monoclonal and Polyclonal Antibodies Research(16), Hemoglobin structure and function(14), Protein Kinase Regulation and GTPase Signaling(12)

Publications137 total

Exploring the Educational Quality of Hospice Videos Available on YouTube (S515)
Journal of Pain and Symptom Management·2022· 1 cited
Usability of PCforMe in Patients With Advanced Cancer Referred to Outpatient Palliative Care: Results of a Randomized, Active-Controlled Pilot Trial
UNC Libraries·2022Open Access
Adherence to
UNC Libraries·2020Open Access
Namensregister
V&R unipress eBooks·2014· 1 citedOpen Access
Identification of 2-Piperidone as a Biomarker of CYP2E1 Activity Through Metabolomic Phenotyping
Toxicological Sciences·2013· 23 citedOpen Access
PNC-27 and PNC-28 anticancer peptides selectively kill cancer cells by pore formation dependent on the binding of these peptides to hdm2 in cancer cell membranes.
Cancer Research·2008· 1 cited
Site-specific phosphorylation of raf in cells containing oncogenic ras-p21 is likely mediated by jun-N-terminal kinase.
PubMed·2008· 3 cited
Two peptides derived from ras-p21 induce either phenotypic reversion or tumor cell necrosis of ras-transformed human cancer cells
Cancer Chemotherapy and Pharmacology·2007· 8 cited
Rapid Conformational Dynamics of Cytochrome P450 2E1 in a Natural Biological Membrane Environment
Biochemistry·2006· 5 cited
PNC‐28, a p53‐derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth <i>in vivo</i>
International Journal of Cancer·2006· 30 cited
Functional Interactions of Raf and MEK with Jun-N-Terminal Kinase (JNK) Result in a Positive Feedback Loop on the Oncogenic Ras Signaling Pathway
Biochemistry·2005· 31 cited
Comparison of Molecular Dynamics Averaged Structures for Complexes of Normal and Oncogenic ras-p21 with SOS Nucleotide Exchange Protein, Containing Computed Conformations for Three Crystallographically Undefined Domains, Suggests a Potential Role of These Domains in ras Signaling
The Protein Journal·2004· 4 cited
Loop Domain Peptides from the SOS ras-Guanine Nucleotide Exchange Protein, Identified from Molecular Dynamics Calculations, Strongly Inhibit ras Signaling
The Protein Journal·2004· 5 cited
An Effector Peptide from Glutathione-S-Transferase-pi Strongly and Selectively Blocks Mitotic Signaling by Oncogenic ras-p21
The Protein Journal·2004· 6 cited
Molecular modeling of mammalian cytochrome P450s
Frontiers in bioscience·2004· 4 citedOpen Access
Peptides designed from molecular modeling studies of the ras -p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on normal pancreatic acinar cell growth
Cancer Chemotherapy and Pharmacology·2003· 16 cited
Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding site
Oncogene·2003· 68 cited
Immunochemical Analysis of Chromatin
Methods in enzymology on CD-ROM/Methods in enzymology·2003· 1 cited
Comparison of the Average Structures, from Molecular Dynamics, of Complexes of GTPase Activating Protein (GAP) with Oncogenic and Wild-Type ras-p21: Identification of Potential Effector Domains
Journal of Protein Chemistry·2002· 7 cited
Inhibition of ras-Induced Oocyte Maturation by Peptides from ras-p21 and GTPase Activating Protein (GAP) Identified as Being Effector Domains from Molecular Dynamics Calculations
Journal of Protein Chemistry·2002· 7 cited
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Frequent Co-authors

Matthew R. Pincus(20), Paul W. Brandt‐Rauf(12), Harry V. Gelboin(9), Richard C. Robinson(8), Renke Dai(8), Victor Adler(6), Ze’ev A. Ronai(6), Denise Chung(6), Aditya P. Koley(5), James Chen(5), Josef Michl(5), Ziro Yamaizumi(5), Allen Markowitz(4), Robert E. Vestal(4), Richard Robinson(4), Robert Robinson(4), Regina Monaco(4), Suoping Zhai(3), Robert L. Fine(3), H V Gelboin(3)