Marc R. Arnone

GlaxoSmithKline (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index913citations9works0.02yr avg
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Research Topics

Melanoma and MAPK Pathways(5), Cutaneous Melanoma Detection and Management(2), Protein Structure and Dynamics(1), Protein Kinase Regulation and GTPase Signaling(1), Computational Drug Discovery Methods(1)

Publications9 total

Dabrafenib; Preclinical Characterization, Increased Efficacy when Combined with Trametinib, while BRAF/MEK Tool Combination Reduced Skin Lesions
PLoS ONE·2013· 212 citedOpen Access
Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors
ACS Medicinal Chemistry Letters·2013· 253 citedOpen Access
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup
Bioorganic & Medicinal Chemistry Letters·2011· 29 citedOpen Access
Abstract 5035: Predictions of therapeutic doses of a B-Raf inhibitor, GSK2118436, based on exposure-response modeling of preclinical tumor biomarker and xenograft data
Cancer Research·2011
Abstract B88: A selective Raf kinase inhibitor induces cell death and tumor regression of human cancer cell lines encoding B-RafV600E mutation
Molecular Cancer Therapeutics·2009· 54 cited
A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues
Proceedings of the National Academy of Sciences·2006· 118 citedOpen Access
Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases
Journal of Medicinal Chemistry·2004· 100 citedOpen Access
Identification of Peptide Substrates for Human MMP-11 (Stromelysin-3) Using Phage Display
Journal of Biological Chemistry·2003· 54 citedOpen Access
Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay
Mutation research. Fundamental and molecular mechanisms of mutagenesis·2002· 93 cited

Frequent Co-authors

Alastair J. King(5), Tara Rheault(4), Sylvie Laquerre(4), Kimberly N. Smitheman(4), Katherine G. Moss(4), David Uehling(4), John Stellwagen(3), George M. Adjabeng(3), Keith R. Hornberger(3), Alex G. Waterson(3), Robert A. Mook(3), Laurie S. Kane-Carson(3), Chao Han(3), Kimberly G. Petrov(2), Scott H. Dickerson(2), Olivia W. Rossanese(2), Maureen R. Bleam(2), Jingsong Yang(2), Robert H. Sinnamon(2), Robert H. Grafström(2)