Timothy R. O’Meara

Brigham and Women's Hospital — United States

Medicine · Health Sciences

9h-index619citations24works14.62yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(10), Immunotherapy and Immune Responses(6), COVID-19 Clinical Research Studies(4), Immune Response and Inflammation(3), Animal Virus Infections Studies(3)

Publications22 total

Discovery of a small molecule TLR3 agonist adjuvant
Nature Communications·2025Open Access
Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2
Science·2025· 1 citedOpen Access
Mutant protein chemical rescue: From mechanisms to therapeutics
Journal of Biological Chemistry·2025· 1 citedOpen Access
BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice
Vaccine·2025· 2 citedOpen Access
The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo
iScience·2024· 4 citedOpen Access
BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice
2024Open Access
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
Journal of Allergy and Clinical Immunology·2023· 19 citedOpen Access
Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice
npj Vaccines·2023· 1 citedOpen Access
Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice
npj Vaccines·2023· 10 citedOpen Access
The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo
2022· 5 citedOpen Access
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
2022· 2 citedOpen Access
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
Communications Biology·2022· 24 citedOpen Access
Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells
2022· 6 citedOpen Access
mRNA booster vaccination protects extremely aged mice against the SARS-CoV-2 Omicron variant
Research Square (Research Square)·2022· 1 citedOpen Access
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
Cell·2022· 116 citedOpen Access
An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice
Science Translational Medicine·2022· 107 cited
An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice.
PubMed·2022· 69 citedOpen Access
An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice
2021· 3 cited
Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity
2021· 13 citedOpen Access
An adjuvant strategy enabled by modulation of the physical properties of fungal mannans elicits pan-coronavirus reactive anti-SARS-CoV-2 Spike antibodies
The Journal of Immunology·2021
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Frequent Co-authors

David J. Dowling(18), Ofer Levy(18), Etsuro Nanishi(16), Marisa E. McGrath(14), Hyuk‐Soo Seo(14), Sirano Dhe‐Paganon(14), Matthew B. Frieman(14), Robert K. Ernst(12), Francesco Borriello(11), Carly Dillen(11), Soumik Barman(11), Manisha Menon(10), Yoshine Saito(9), Al Ozonoff(9), Ivan Zanoni(8), Byron Brook(8), Joann Diray‐Arce(8), Kijun Song(8), Andrew Z. Xu(8), Lindsey R. Baden(8)