Robin J. Kleiman

Cambridge Systematics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index3.4kcitations63works2.72yr avg
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Research Topics

Phosphodiesterase function and regulation(20), Cholinesterase and Neurodegenerative Diseases(14), Autism Spectrum Disorder Research(9), Genetics and Neurodevelopmental Disorders(9), RNA Research and Splicing(8)

Publications63 total

A community-led initiative to de-risk and advance Parkinson’s disease therapeutic targets
npj Parkinson s Disease·2025· 2 citedOpen Access
Cis-regulatory elements driving motor neuron-selective viral payload expression within the mammalian spinal cord
Proceedings of the National Academy of Sciences·2024· 4 citedOpen Access
Cis-regulatory elements driving motor neuron-restricted viral payload expression within the mammalian spinal cord
2024· 2 citedOpen Access
16p13.11 deletion variants associated with neuropsychiatric disorders cause morphological and synaptic changes in induced pluripotent stem cell-derived neurons
Frontiers in Psychiatry·2022· 1 citedOpen Access
Developing clinically translatable screens using iPSC-derived neural cells
Elsevier eBooks·2022
Contributors
Elsevier eBooks·2022
Gene-based therapeutics for rare genetic neurodevelopmental psychiatric disorders
Molecular Therapy·2022· 23 citedOpen Access
Human inducible pluripotent stem cells: Realization of initial promise in drug discovery
Cell stem cell·2021· 43 citedOpen Access
Generation and characterization of human induced pluripotent stem cells (iPSCs) from three male and three female patients with CDKL5 Deficiency Disorder (CDD)
Stem Cell Research·2021· 11 citedOpen Access
Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia
Cell Reports·2020· 25 citedOpen Access
How to develop therapeutic and translational research collaborations with industry
Molecular Biology of the Cell·2019· 6 citedOpen Access
A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport
Cell Reports·2019· 46 citedOpen Access
Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder
Translational Psychiatry·2019· 179 citedOpen Access
Best Practices for Translational Disease Modeling Using Human iPSC-Derived Neurons
Neuron·2018· 143 citedOpen Access
De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome
Molecular Genetics and Metabolism Reports·2018· 18 citedOpen Access
Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Journal of Medicinal Chemistry·2018
Withdrawn Article
Molecular Genetics and Metabolism Reports·2018Open Access
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate
Journal of Medicinal Chemistry·2018· 27 citedOpen Access
Translating genetic and preclinical findings into autism therapies
Dialogues in Clinical Neuroscience·2017· 10 citedOpen Access
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Journal of Medicinal Chemistry·2017· 32 citedOpen Access
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Frequent Co-authors

Frank S. Menniti(11), Thomas A. Lanz(7), Diane Stephenson(7), Wendy O. Adamowicz(7), Christopher J. Schmidt(7), Patrick R. Verhoest(7), Susan E. Bove(6), John F. Harms(6), Christopher J. Helal(6), Gary Banker(5), Oswald Steward(5), Frederick Nelson(5), Daniel Morton(4), Kari R. Fonseca(4), Mihály Hajós(4), Anne W. Schmidt(4), Michelle Vanase‐Frawley(4), Mustafa Şahin(4), Veronica Reinhart(3), Abigail Mariga(3)