Patrick R. Verhoest

Pfizer (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index7.2kcitations108works26.32yr avg
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Research Topics

Receptor Mechanisms and Signaling(16), Cholinesterase and Neurodegenerative Diseases(16), Phosphodiesterase function and regulation(16), Computational Drug Discovery Methods(12), Chemical synthesis and alkaloids(11)

Publications108 total

Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease
Journal of Medicinal Chemistry·2025· 15 cited
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer’s Disease
Journal of Medicinal Chemistry·2024· 5 citedOpen Access
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19
Journal of Medicinal Chemistry·2024· 59 citedOpen Access
CCDC 2210556: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
An oral SARS-CoV-2 M <sup>pro</sup> inhibitor clinical candidate for the treatment of COVID-19
Science·2021· 1.8k citedOpen Access
Designing small molecules for therapeutic success: A contemporary perspective
Drug Discovery Today·2021· 31 citedOpen Access
An Oral SARS-CoV-2 M <sup>pro</sup> Inhibitor Clinical Candidate for the Treatment of COVID-19
2021· 23 citedOpen Access
Innovation in breakthrough drugs and vaccines: Development risk, patient impact, and value
Drug Discovery Today·2021· 3 citedOpen Access
Harnessing Preclinical Data as a Predictive Tool for Human Brain Tissue Targeting
ACS Chemical Neuroscience·2021· 9 cited
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE
Cell chemical biology·2020· 26 cited
CCDC 1993705: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify Liver X Receptor β as the Functional Target of Enhancers of Astrocytic Apolipoprotein E
SSRN Electronic Journal·2020Open Access
Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition
Molecular Pharmacology·2018· 7 citedOpen Access
Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Journal of Medicinal Chemistry·2018
Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189
ACS Medicinal Chemistry Letters·2018· 38 citedOpen Access
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate
Journal of Medicinal Chemistry·2018· 27 citedOpen Access
The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging
Journal of Medicinal Chemistry·2017· 36 cited
Discovery and Characterization of (<i>R</i>)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-<i>c</i>][1,4]oxazin-4(9<i>H</i>)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates
Journal of Medicinal Chemistry·2017· 9 citedOpen Access
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Journal of Medicinal Chemistry·2017· 32 citedOpen Access
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy
MedChemComm·2016· 17 citedOpen Access
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Frequent Co-authors

Jamison B. Tuttle(12), Xinjun Hou(11), Travis T. Wager(10), Christopher J. Helal(10), Kari R. Fonseca(9), Martin Pettersson(7), Jayvardhan Pandit(7), Anne W. Schmidt(7), John M. Humphrey(7), Edelweiss Evrard(7), Karen J. Coffman(6), Anabella Villalobos(6), Frank S. Menniti(6), Bethany L. Kormos(6), Amy B. Dounay(6), Gregory W. Kauffman(6), Bruce M. Bechle(6), Laura A. McAllister(6), Vinod D. Parikh(6), Robin J. Kleiman(6)